Description
Product Name: | Phospho-IRS1-S612 Rabbit pAb |
Product Code: | CABP0553 |
Size: | 20uL, 50uL, 100uL |
Synonyms: | HIRS-1, IRS1 |
Applications: | WB, IHC |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S612 of human IRS1 |
Applications: | WB, IHC |
Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | C2C12 |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S612 of human IRS1 |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 3667 |
Uniprot: | P35568 |
Calculated MW: | 131kDa |
Observed MW: | 180KDa |
UniProt Protein Function: | IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q36 Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; cytosol; nucleus Molecular Function:insulin-like growth factor receptor binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; glucose homeostasis; signal transduction; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration Disease: Diabetes Mellitus, Noninsulin-dependent |
NCBI Summary: | This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] |
UniProt Code: | P35568 |
NCBI GenInfo Identifier: | 547738 |
NCBI Gene ID: | 3667 |
NCBI Accession: | P35568.1 |
UniProt Related Accession: | P35568 |
Molecular Weight: | |
NCBI Full Name: | Insulin receptor substrate 1 |
NCBI Synonym Full Names: | insulin receptor substrate 1 |
NCBI Official Symbol: | IRS1 |
NCBI Official Synonym Symbols: | HIRS-1 |
NCBI Protein Information: | insulin receptor substrate 1; IRS-1 |
UniProt Protein Name: | Insulin receptor substrate 1 |
Protein Family: | Isoleucine--tRNA ligase |
UniProt Gene Name: | IRS1 |
UniProt Entry Name: | IRS1_HUMAN |