Anti-Phospho-IRE1-Ser729 Antibody (CABP0960)
- SKU:
- CABP0960
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERN1
- Synonyms:
- IRE1
- Synonyms:
- IRE1P
- Synonyms:
- IRE1a
- Synonyms:
- hIRE1p
- Research Area:
- Cell Death
Description
| Product Name: | Phospho-IRE1-Ser729 Rabbit pAb |
| Product Code: | CABP0960 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ERN1, IRE1, IRE1P, IRE1a, hIRE1p |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around of human Phospho-IRE1-Ser729. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Immunogen: | A synthetic phosphorylated peptide around of human Phospho-IRE1-Ser729. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2081 |
| Uniprot: | O75460 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
| Calculated MW: | 6kDa/109kDa |
| Observed MW: | Refer to figures |
| NCBI Summary: | This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017] |
| UniProt Code: | O75460 |
| NCBI GenInfo Identifier: | 193806335 |
| NCBI Gene ID: | 2081 |
| NCBI Accession: | O75460.2 |
| UniProt Secondary Accession: | O75460,Q76MJ5, |
| UniProt Related Accession: | O75460 |
| Molecular Weight: | Observed: 110 kDaPredicted: 110 kDa |
| NCBI Full Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| NCBI Synonym Full Names: | endoplasmic reticulum to nucleus signaling 1 |
| NCBI Official Symbol: | ERN1 |
| NCBI Official Synonym Symbols: | IRE1; IRE1P; IRE1a; hIRE1p |
| NCBI Protein Information: | serine/threonine-protein kinase/endoribonuclease IRE1 |
| UniProt Protein Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
| UniProt Synonym Protein Names: | Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a |
| Protein Family: | Serine/threonine-protein kinase/endoribonuclease |
| UniProt Gene Name: | ERN1 |
| UniProt Entry Name: | ERN1_HUMAN |
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