Cell Biology Antibodies 16
Anti-Phospho-INSR-Y1146/IGF1R-Y1131 pAb Antibody (CABP0863)
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- SKU:
- CABP0863
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-Phospho-INSR-Y1146/IGF1R-Y1131 Antibody |
| Antibody SKU: | CABP0863 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, HeLa |
| Immunogen: | A synthetic phosphorylated peptide around Y1146 of human INSR and Y1131 of human IGF1R. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3643/3480 |
| Uniprot: | P06213/P08069 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 155kDa |
| Observed MW: | 95kDa |
 | Western blot analysis of extracts of various cell lines, using Phospho-INSR-Y1146/IGF1R-Y1131 Rabbit pAb (CABP0863) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
| Synonyms: | INSR/IGF1R |
| Background: | This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] |
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