Immunology Antibodies 3
Anti-Phospho-IKBKB-Y199 Antibody (CABP0369)
- SKU:
- CABP0369
- Product Type:
- Antibody
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-Phospho-IKBKB-Y199 Antibody |
| Antibody SKU: | CABP0369 |
| Antibody Size: | 100 uL |
| Application: | IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y199 of human IKKBeta |
| Application: | IF |
| Recommended Dilution: | IF 1:100 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y199 of human IKKBeta |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 3551 |
| Uniprot: | O14920 |
| Cellular Location: | Cytoplasm, Membrane raft, Nucleus |
| Calculated MW: | 29kDa/79kDa/85kDa/86kDa |
| Observed MW: |
 | Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-IKKb-Y199 antibody (CABP0369). |
| Synonyms: | IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, IKK beta |
| Background: | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. |
| UniProt Protein Function: | IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft Molecular Function:protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis Disease: Immunodeficiency 15 |
| NCBI Summary: | The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | O14920 |
| NCBI GenInfo Identifier: | 14285497 |
| NCBI Gene ID: | 3551 |
| NCBI Accession: | O14920.1 |
| UniProt Secondary Accession: | O14920,O75327, B4DZ30, B4E0U4, |
| UniProt Related Accession: | O14920 |
| Molecular Weight: | 86,564 Da |
| NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
| NCBI Official Symbol: | IKBKB |
| NCBI Official Synonym Symbols: | IKK2; IKKB; IMD15; NFKBIKB; IKK-beta |
| NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta |
| UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit beta |
| UniProt Synonym Protein Names: | I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta |
| UniProt Gene Name: | IKBKB |
| UniProt Entry Name: | IKKB_HUMAN |
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