Epigenetics & Nuclear Signaling Antibodies 4
Anti-Phospho-HDAC8-S39 Antibody (CABP0360)
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- SKU:
- CABP0360
- Product Type:
- Antibody
- Applications:
- IHC
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Phospho-HDAC8-S39 Antibody |
| Antibody SKU: | CABP0360 |
| Antibody Size: | 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S39 of human HDAC8 |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:100 IF 1:100 - 1:200 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S39 of human HDAC8 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55869 |
| Uniprot: | Q9BY41 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 15kDa/16kDa/17kDa/28kDa/29kDa/31kDa/41kDa |
| Observed MW: |
 | Immunohistochemistry of paraffin-embedded human lung carcinoma using Phospho-HDAC8-S39 antibody (CABP0360). |
 | Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-HDAC8-S39 antibody (CABP0360). |
| Synonyms: | HDAC8, CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS |
| Background: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | HDAC8: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility. Belongs to the histone deacetylase family. HD type 1 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.5.1.98; Hydrolase Chromosomal Location of Human Ortholog: Xq13 Cellular Component: nucleoplasm; nuclear chromosome; histone deacetylase complex; cytoplasm; plasma membrane; cytosol; nucleus Molecular Function:NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding Biological Process: chromatin assembly or disassembly; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; sister chromatid cohesion; mitotic cell cycle; chromatin modification; negative regulation of transcription from RNA polymerase II promoter Disease: Wilson-turner X-linked Mental Retardation Syndrome |
| NCBI Summary: | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9BY41 |
| NCBI GenInfo Identifier: | 29839394 |
| NCBI Gene ID: | 55869 |
| NCBI Accession: | Q9BY41.2 |
| UniProt Secondary Accession: | Q9BY41,Q86VC8, Q9NP76, Q9NYH4, A6ND12, A6ND61, A6NET3 A6NJR3, A8MQ62, B4DKN0, B4DV22, |
| UniProt Related Accession: | Q9BY41 |
| Molecular Weight: | 377 |
| NCBI Full Name: | Histone deacetylase 8 |
| NCBI Synonym Full Names: | histone deacetylase 8 |
| NCBI Official Symbol: | HDAC8 |
| NCBI Official Synonym Symbols: | HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1 |
| NCBI Protein Information: | histone deacetylase 8; histone deacetylase-like 1 |
| UniProt Protein Name: | Histone deacetylase 8 |
| UniProt Gene Name: | HDAC8 |
| UniProt Entry Name: | HDAC8_HUMAN |
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