Metabolism Antibodies 3
Anti-Phospho-GYS1-S641 pAb Antibody (CABP0877)
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- SKU:
- CABP0877
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-Phospho-GYS1-S641 Antibody |
| Antibody SKU: | CABP0877 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S641 of human GYS1 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, NIH/3T3, C6 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S641 of human GYS1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2997 |
| Uniprot: | P13807 |
| Cellular Location: | |
| Calculated MW: | 76kDa/83kDa |
| Observed MW: | 100kDa |
 | Western blot analysis of extracts of various cell lines, using Phospho-GYS1-S641 antibody (CABP0877) at 1:1000 dilution.NIH/3T3 cells and C6 cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Western blot analysis of extracts of 293T cells, using Anti-Phospho-GYS1-S641 pAb (CABP0877) at 1:1000 dilution or GYS1 antibody (CAB2519).293T cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
| Synonyms: | GYS1, GSY, GYS |
| Background: | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1, 4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | GYS1: muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: membrane; cytoplasm; inclusion body; cytosol Molecular Function:protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process; pathogenesis Disease: Glycogen Storage Disease 0, Muscle |
| NCBI Summary: | The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P13807 |
| NCBI GenInfo Identifier: | 1351366 |
| NCBI Gene ID: | 2997 |
| NCBI Accession: | P13807.2 |
| UniProt Secondary Accession: | P13807,Q9BTT9, |
| UniProt Related Accession: | P13807 |
| Molecular Weight: | 737 |
| NCBI Full Name: | Glycogen |
| NCBI Synonym Full Names: | glycogen synthase 1 (muscle) |
| NCBI Official Symbol: | GYS1 |
| NCBI Official Synonym Symbols: | GSY; GYS |
| NCBI Protein Information: | glycogen [starch] synthase, muscle; glycogen [starch] synthase, muscle |
| UniProt Protein Name: | Glycogen [starch] synthase, muscle |
| Protein Family: | Glycogen [starch] synthase |
| UniProt Gene Name: | GYS1 |
| UniProt Entry Name: | GYS1_HUMAN |
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