Anti-Phospho-FOXO3A-S425 Antibody (CABP1200)

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SKU:
CABP1200
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AF6q21
Synonyms:
FKHRL1
Synonyms:
FKHRL1P2
Synonyms:
FOXO2
Synonyms:
FOXO3A
Research Area:
Cell Death

Description

Product Name:Phospho-FOXO3A-S425 Rabbit pAb
Product Code:CABP1200
Size:50uL, 100uL
Synonyms:AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Applications:WB, IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around S425 of human FOXO3A.
Applications:WB, IHC
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:K-562
Immunogen:A synthetic phosphorylated peptide around S425 of human FOXO3A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2309
Uniprot:O43524
Observed MW:82KDa
UniProt Protein Function:FOXO3A: a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia.
UniProt Protein Details:

Protein type:Oncoprotein; DNA-binding; Transcription factor; Autophagy

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol; nucleus

Molecular Function:protein binding; DNA binding; chromatin DNA binding; sequence-specific DNA binding; transcription factor activity; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; nerve growth factor receptor signaling pathway; initiation of primordial ovarian follicle growth; positive regulation of transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; oocyte maturation; regulation of translation; regulation of transcription from RNA polymerase II promoter; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:O43524
NCBI GenInfo Identifier:8134467
NCBI Gene ID:2309
NCBI Accession:O43524.1
UniProt Secondary Accession:O43524,O15171, Q5T2I7, Q9BZ04, B4DVZ6, E1P5E6,
UniProt Related Accession:O43524
Molecular Weight:
NCBI Full Name:Forkhead box protein O3
NCBI Synonym Full Names:forkhead box O3
NCBI Official Symbol:FOXO3  
NCBI Official Synonym Symbols:FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2  
NCBI Protein Information:forkhead box protein O3; forkhead box O3A; forkhead in rhabdomyosarcoma-like 1; forkhead homolog (rhabdomyosarcoma) like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
UniProt Protein Name:Forkhead box protein O3
UniProt Synonym Protein Names:AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1
Protein Family:Forkhead box protein
UniProt Gene Name:FOXO3  
UniProt Entry Name:FOXO3_HUMAN
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