Cell Cycle Antibodies 2
Anti-Phospho-ERK3-S189 Antibody (CABP0051)
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- SKU:
- CABP0051
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
| Antibody Name: | Anti-Phospho-ERK3-S189 Antibody |
| Antibody SKU: | CABP0051 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S189 of human ERK3 (NP_002739.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293 |
| Immunogen: | A synthetic phosphorylated peptide around S189 of human ERK3 (NP_002739.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HLSE G |
| Gene ID: | 5597 |
| Uniprot: | Q16659 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 82kDa |
| Observed MW: | 120kDa |
 | Western blot analysis of extracts of 293 cells, using Phospho-ERK3-S189 antibody (CABP0051) at 1:1000 dilution. 293 cells were treated by PMA/TPA (200nM) for 30 minutes after serum-starvation overnight. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. |
| Synonyms: | MAPK6, ERK3, HsT17250, PRKM6, p97MAPK |
| Background: | The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. |
| UniProt Protein Function: | ERK3: a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily Chromosomal Location of Human Ortholog: 15q21 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:MAP kinase activity; protein binding; protein serine/threonine kinase activity Biological Process: protein amino acid phosphorylation; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16659 |
| NCBI GenInfo Identifier: | 2499596 |
| NCBI Gene ID: | 5597 |
| NCBI Accession: | Q16659.1 |
| UniProt Secondary Accession: | Q16659,Q68DH4, Q8IYN8, B2R945, B5BU65, |
| UniProt Related Accession: | Q16659 |
| Molecular Weight: | 82,681 Da |
| NCBI Full Name: | Mitogen-activated protein kinase 6 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase 6 |
| NCBI Official Symbol: | MAPK6 |
| NCBI Official Synonym Symbols: | ERK3; PRKM6; p97MAPK; HsT17250 |
| NCBI Protein Information: | mitogen-activated protein kinase 6 |
| UniProt Protein Name: | Mitogen-activated protein kinase 6 |
| UniProt Synonym Protein Names: | Extracellular signal-regulated kinase 3; ERK-3; MAP kinase isoform p97; p97-MAPK |
| UniProt Gene Name: | MAPK6 |
| UniProt Entry Name: | MK06_HUMAN |
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