Developmental Biology
Anti-Phospho-DPYSL2-T514 pAb Antibody (CABP0821)
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- SKU:
- CABP0821
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Description
| Antibody Name: | Anti-Phospho-DPYSL2-T514 Antibody |
| Antibody SKU: | CABP0821 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T514 of human DPYSL2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, PC-12 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding T514 of human DPYSL2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1808 |
| Uniprot: | Q16555 |
| Cellular Location: | Cytoplasm, Membrane, cytoskeleton, cytosol |
| Calculated MW: | 58kDa/62kDa |
| Observed MW: | 69kDa |
 | Western blot analysis of extracts of various cell lines, using Phospho-DPYSL2-T514 antibody (CABP0821) at 1:1000 dilution or DPYSL2 antibody (CAB14570). SH-SY5Y cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. PC-12 cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| Synonyms: | DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2 |
| Background: | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)). |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Microtubule-binding Chromosomal Location of Human Ortholog: 8p22-p21 Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol Molecular Function:protein binding; dihydropyrimidinase activity; protein kinase binding Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| NCBI Summary: | This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q16555 |
| NCBI GenInfo Identifier: | 3122051 |
| NCBI Gene ID: | 1808 |
| NCBI Accession: | Q16555.1 |
| UniProt Secondary Accession: | Q16555,O00424, A8K5H2, B4DR31, D3DSS7, |
| UniProt Related Accession: | Q16555 |
| Molecular Weight: | |
| NCBI Full Name: | Dihydropyrimidinase-related protein 2 |
| NCBI Synonym Full Names: | dihydropyrimidinase-like 2 |
| NCBI Official Symbol: | DPYSL2 |
| NCBI Official Synonym Symbols: | DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2 |
| NCBI Protein Information: | dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2 |
| UniProt Protein Name: | Dihydropyrimidinase-related protein 2 |
| UniProt Synonym Protein Names: | Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2 |
| Protein Family: | Dihydropyrimidinase-related protein |
| UniProt Gene Name: | DPYSL2 |
| UniProt Entry Name: | DPYL2_HUMAN |
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