Anti-Phospho-DARPP32-T34 Antibody (CABP1198)
- SKU:
- CABP1198
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- DARPP-32
- Synonyms:
- DARPP32
- Research Area:
- Cell Biology
Description
| Product Name: | Phospho-DARPP32-T34 Rabbit pAb |
| Product Code: | CABP1198 |
| Size: | 50uL, 100uL |
| Synonyms: | DARPP-32, DARPP32 |
| Applications: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around T34 of human DARPP32. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Immunogen: | A synthetic phosphorylated peptide around T34 of human DARPP32. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 84152 |
| Uniprot: | Q9UD71 |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | DARPP-32: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 17q12 Cellular Component: cell soma; cytoplasm; cytosol; nucleus Molecular Function:D1 dopamine receptor binding; D2 dopamine receptor binding; D3 dopamine receptor binding; D4 dopamine receptor binding; D5 dopamine receptor binding; protein binding; protein kinase inhibitor activity; protein phosphatase inhibitor activity; protein phosphatase type 1 regulator activity; type 1 serine/threonine specific protein phosphatase inhibitor activity Biological Process: negative regulation of catalytic activity; negative regulation of female receptivity; regulation of catalytic activity; response to amphetamine; signal transduction; transcription, DNA-dependent; visual learning |
| NCBI Summary: | This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9UD71 |
| NCBI GenInfo Identifier: | 23831292 |
| NCBI Gene ID: | 84152 |
| NCBI Accession: | Q9UD71.2 |
| UniProt Secondary Accession: | Q9UD71,Q547V9, Q547W0, Q9H7G1, |
| UniProt Related Accession: | Q9UD71 |
| Molecular Weight: | 18,738 Da |
| NCBI Full Name: | Protein phosphatase 1 regulatory subunit 1B |
| NCBI Synonym Full Names: | protein phosphatase 1 regulatory inhibitor subunit 1B |
| NCBI Official Symbol: | PPP1R1B |
| NCBI Official Synonym Symbols: | DARPP32; DARPP-32 |
| NCBI Protein Information: | protein phosphatase 1 regulatory subunit 1B |
| UniProt Protein Name: | Protein phosphatase 1 regulatory subunit 1B |
| UniProt Synonym Protein Names: | DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein |
| Protein Family: | Protein phosphatase 1 regulatory |
| UniProt Gene Name: | PPP1R1B |
| UniProt Entry Name: | PPR1B_HUMAN |
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