Anti-Phospho-CENPA-S7 Antibody (CABP1183)
- SKU:
- CABP1183
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CENP-A
- Synonyms:
- CenH3
- Research Area:
- Cell Cycle
Description
| Product Name: | Phospho-CENPA-S7 Rabbit pAb |
| Product Code: | CABP1183 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CENP-A, CenH3 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1). |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | A synthetic phosphorylated peptide around S7 of human CENPA (NP_001035891.1). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1058 |
| Uniprot: | P49450 |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | CENPA: a basic nuclear protein of the histone H3 family. May act as a core histone necessary for the assembly of centromeres. Contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: chromosome, pericentric region; condensed nuclear chromosome, pericentric region; cytosol; nucleoplasm; nucleus Molecular Function:chromatin binding; protein binding Biological Process: DNA replication-independent nucleosome assembly at centromere; establishment of mitotic spindle orientation; kinetochore assembly; sister chromatid cohesion |
| NCBI Summary: | Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P49450 |
| NCBI GenInfo Identifier: | 1345726 |
| NCBI Gene ID: | 1058 |
| NCBI Accession: | P49450.1 |
| UniProt Secondary Accession: | P49450,Q53T74, Q9BVW2, D6W544, |
| UniProt Related Accession: | P49450 |
| Molecular Weight: | 13,001 Da |
| NCBI Full Name: | Histone H3-like centromeric protein A |
| NCBI Synonym Full Names: | centromere protein A |
| NCBI Official Symbol: | CENPA |
| NCBI Official Synonym Symbols: | CenH3; CENP-A |
| NCBI Protein Information: | histone H3-like centromeric protein A |
| UniProt Protein Name: | Histone H3-like centromeric protein A |
| UniProt Synonym Protein Names: | Centromere autoantigen A; Centromere protein A; CENP-A |
| Protein Family: | Histone H3-like centromeric protein |
| UniProt Gene Name: | CENPA |
| UniProt Entry Name: | CENPA_HUMAN |
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