Description
| Product Name: | Phospho-API5-S464 Rabbit pAb |
| Product Code: | CABP1247 |
| Size: | 50uL, 100uL |
| Synonyms: | AAC11, AAC-11 |
| Applications: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S464 of Human API5. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Immunogen: | A phospho synthetic peptide corresponding to residues surrounding S464 of Human API5. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8539 |
| Uniprot: | Q9BZZ5 |
| Calculated MW: | 59kDa |
| Observed MW: | Refer to figures |
| UniProt Protein Function: | API5: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Apoptosis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus Molecular Function:protein binding; fibroblast growth factor binding Biological Process: apoptosis; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q9BZZ5 |
| NCBI GenInfo Identifier: | 353526346 |
| NCBI Gene ID: | 8539 |
| NCBI Accession: | Q9BZZ5.3 |
| UniProt Secondary Accession: | Q9BZZ5,O15441, Q9Y4J7, B4DGR0, B4DRJ2, D3DR21, |
| UniProt Related Accession: | Q9BZZ5 |
| Molecular Weight: | 50,740 Da |
| NCBI Full Name: | Apoptosis inhibitor 5 |
| NCBI Synonym Full Names: | apoptosis inhibitor 5 |
| NCBI Official Symbol: | API5Â Â |
| NCBI Official Synonym Symbols: | AAC11; AAC-11Â Â |
| NCBI Protein Information: | apoptosis inhibitor 5; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein; fibroblast growth factor 2-interacting factor 2 |
| UniProt Protein Name: | Apoptosis inhibitor 5 |
| UniProt Synonym Protein Names: | Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL |
| Protein Family: | Apoptosis inhibitor |
| UniProt Gene Name: | API5Â Â |
| UniProt Entry Name: | API5_HUMAN |
