Cell Biology Antibodies 18
Anti-PHLPP2 Antibody (CAB18218)
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- SKU:
- CAB18218
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PHLPP2 Antibody |
| Antibody SKU: | CAB18218 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PHLPP2. |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse eye, Rat eye |
| Immunogen: | Recombinant protein of human PHLPP2. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 23035 |
| Uniprot: | Q6ZVD8 |
| Cellular Location: | |
| Calculated MW: | 147kDa |
| Observed MW: | 140kDa |
 | Western blot - PHLPP2 Polyclonal Antibody (CAB18218) |
| Synonyms: | PHLPP2, PHLPPL, PPM3B |
| Background: |
| UniProt Protein Function: | PHLPP2: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Tumor suppressor; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: cytoplasm; cytosol |
| UniProt Code: | Q6ZVD8 |
| NCBI GenInfo Identifier: | 116242711 |
| NCBI Gene ID: | 23035 |
| NCBI Accession: | Q6ZVD8.3 |
| UniProt Secondary Accession: | Q6ZVD8,Q9NV17, Q9Y2E3, A1L374, |
| UniProt Related Accession: | Q6ZVD8 |
| Molecular Weight: | 139,394 Da |
| NCBI Full Name: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
| NCBI Synonym Full Names: | PH domain and leucine rich repeat protein phosphatase 2 |
| NCBI Official Symbol: | PHLPP2 |
| NCBI Official Synonym Symbols: | PPM3B; PHLPPL |
| NCBI Protein Information: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
| UniProt Protein Name: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
| UniProt Synonym Protein Names: | PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like |
| Protein Family: | PH domain leucine-rich repeat-containing protein phosphatase |
| UniProt Gene Name: | PHLPP2 |
| UniProt Entry Name: | PHLP2_HUMAN |
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