Epigenetics & Nuclear Signaling Antibodies 5
Anti-PHB2 Antibody (CAB9144)
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- SKU:
- CAB9144
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-PHB2 Antibody |
| Antibody SKU: | CAB9144 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PHB2 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SKOV3, HT-1080, NIH/3T3, C6, Mouse liver, Mouse heart |
| Immunogen: | A synthesized peptide derived from human PHB2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11331 |
| Uniprot: | Q99623 |
| Cellular Location: | Cytoplasm, Mitochondrion inner membrane, Nucleus |
| Calculated MW: | 30kDa |
| Observed MW: | 33KDa |
| Synonyms: | BAP, BCAP37, Bap37, PNAS-141, REA, hBAP, p22, PHB2 |
| Background: |
| UniProt Protein Function: | BAP37: a protein of the band 7 family. This family includes the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. A repressor of estrogen receptor (ER) activity. Reverses steroid receptor coactivator 1 enhancement of ER activity. May play a role in determining the sensitivity of estrogen target cells to antiestrogen and estrogen therapy. |
| UniProt Protein Details: | Protein type:Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 12p13 Cellular Component: protein complex; nuclear matrix; mitochondrion; mitochondrial inner membrane; nucleus Molecular Function:protein binding; estrogen receptor binding Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of mammary gland epithelial cell proliferation; negative regulation of estrogen receptor signaling pathway |
| UniProt Code: | Q99623 |
| NCBI GenInfo Identifier: | 74752151 |
| NCBI Gene ID: | |
| NCBI Accession: | Q99623.2 |
| Molecular Weight: | |
| NCBI Full Name: | Prohibitin-2 |
| UniProt Protein Name: | Prohibitin-2 |
| UniProt Synonym Protein Names: | B-cell receptor-associated protein BAP37; D-prohibitin; Repressor of estrogen receptor activity |
| Protein Family: | Readthrough protein |
| UniProt Gene Name: | PHB2 |
| UniProt Entry Name: | PHB2_HUMAN |
 | Western blot - PHB2 Rabbit mAb (CAB9144) |
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