Cell Biology Antibodies 9
Anti-PGRMC1 Antibody (CAB5619)
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- SKU:
- CAB5619
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PGRMC1 Antibody |
| Antibody SKU: | CAB5619 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-195 of human PGRMC1 (NP_006658.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, 293T, SW480, OVCAR3, NCI-H460, Mouse liver, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 44-195 of human PGRMC1 (NP_006658.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KIVR GDQP AASG DSDD DEPP PLPR LKRR DFTP AELR RFDG VQDP RILM AING KVFD VTKG RKFY GPEG PYGV FAGR DASR GLAT FCLD KEAL KDEY DDLS DLTA AQQE TLSD WESQ FTFK YHHV GKLL KEGE EPTV YSDE EEPK DESA RKND |
| Gene ID: | 10857 |
| Uniprot: | O00264 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Single-pass membrane protein |
| Calculated MW: | 15kDa/21kDa |
| Observed MW: | 24kDa |
| Synonyms: | PGRMC1, HPR6.6, MPR |
| Background: | This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. |
| UniProt Protein Function: | PGRMC1: Receptor for progesterone. Widely expressed, with highest expression in liver and kidney. Belongs to the cytochrome b5 family. MAPR subfamily. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq22-q24 Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; nucleolus Molecular Function:protein binding; heme binding; steroid binding Biological Process: axon guidance |
| NCBI Summary: | This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010] |
| UniProt Code: | O00264 |
| NCBI GenInfo Identifier: | 6647589 |
| NCBI Gene ID: | 10857 |
| NCBI Accession: | O00264.3 |
| UniProt Secondary Accession: | O00264,Q9UGJ9, B7Z1L3, |
| UniProt Related Accession: | O00264 |
| Molecular Weight: | 195 |
| NCBI Full Name: | Membrane-associated progesterone receptor component 1 |
| NCBI Synonym Full Names: | progesterone receptor membrane component 1 |
| NCBI Official Symbol: | PGRMC1 |
| NCBI Official Synonym Symbols: | MPR; HPR6.6 |
| NCBI Protein Information: | membrane-associated progesterone receptor component 1; progesterone binding protein |
| UniProt Protein Name: | Membrane-associated progesterone receptor component 1 |
| Protein Family: | Membrane-associated progesterone receptor component |
| UniProt Gene Name: | PGRMC1 |
| UniProt Entry Name: | PGRC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PGRMC1 antibody (CAB5619) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using PGRMC1 antibody (CAB5619) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human tonsil using PGRMC1 antibody (CAB5619) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human vermiform appendix using PGRMC1 antibody (CAB5619) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using PGRMC1 antibody (CAB5619) at dilution of 1:100 (40x lens). |
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