Signal Transduction Antibodies 3
Anti-PGP9.5 Antibody (CAB19101)
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- SKU:
- CAB19101
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-PGP9.5 Antibody |
| Antibody SKU: | CAB19101 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PGP9.5 |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, DU145, SH-SY5Y, A-549, Mouse brain, Rat brain |
| Immunogen: | A synthesized peptide derived from human PGP9.5 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7345 |
| Uniprot: | P09936 |
| Cellular Location: | |
| Calculated MW: | 25kDa |
| Observed MW: | 27kDa |
 | Western blot - PGP9.5 Rabbit mAb (CAB19101) |
| Synonyms: | HEL-117, HEL-S-53, NDGOA, PARK5, PGP 9.5, PGP9.5, PGP95, SPG79, Uch-L1, UCHL1 |
| Background: | The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] |
| UniProt Protein Function: | UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Cell development/differentiation; Ligase; Protease; EC 3.4.19.12 Chromosomal Location of Human Ortholog: 4p14 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; cell soma; axon; cytoplasm; plasma membrane; cytosol Molecular Function:ubiquitin binding; omega peptidase activity; protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity Biological Process: cell proliferation; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of MAP kinase activity; axon transport of mitochondrion; protein deubiquitination; axon target recognition; eating behavior; neuromuscular process; muscle fiber development; sensory perception of pain; adult walking behavior Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant |
| NCBI Summary: | The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P09936 |
| NCBI GenInfo Identifier: | 136681 |
| NCBI Gene ID: | 7345 |
| NCBI Accession: | P09936.2 |
| UniProt Secondary Accession: | P09936,Q4W5K6, Q71UM0, |
| UniProt Related Accession: | P09936 |
| Molecular Weight: | 223 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| NCBI Synonym Full Names: | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| NCBI Official Symbol: | UCHL1 |
| NCBI Official Synonym Symbols: | NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
| UniProt Synonym Protein Names: | Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | UCHL1 |
| UniProt Entry Name: | UCHL1_HUMAN |
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