Immunology Antibodies 1

Anti-PGLYRP1 Antibody (CAB10460)

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SKU:
CAB10460
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-PGLYRP1 Antibody
Antibody SKU:CAB10460
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human PGLYRP1 (NP_005082.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:293T, LO2, HL-60
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human PGLYRP1 (NP_005082.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QETE DPAC CSPI VPRN EWKA LASE CAQH LSLP LRYV VVSH TAGS SCNT PASC QQQA RNVQ HYHM KTLG WCDV GYNF LIGE DGLV YEGR GWNF TGAH SGHL WNPM SIGI SFMG NYMD RVPT PQAI RAAQ GLLA CGVA QGAL RSNY VLKG HRDV QRTL SPGN QLYH LIQN WPHY RSP
Gene ID:8993
Uniprot:O75594
Cellular Location:Cytoplasmic granule, Secreted
Calculated MW:21kDa
Observed MW:35kDa
Synonyms:PGLYRP1, PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L
Background:
UniProt Protein Function:PGLYRP1: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Apoptosis; Receptor, misc.; Secreted

Chromosomal Location of Human Ortholog: 19q13.2-q13.3

Cellular Component: extracellular region

Molecular Function:peptidoglycan receptor activity; peptidoglycan binding; zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity

Biological Process: defense response to Gram-positive bacterium; negative regulation of natural killer cell differentiation during immune response; detection of bacterium; negative regulation of interferon-gamma production; negative regulation of inflammatory response; innate immune response; immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process

UniProt Code:O75594
NCBI GenInfo Identifier:18202143
NCBI Gene ID:8993
NCBI Accession:O75594.1
UniProt Secondary Accession:O75594,Q4VB36,
UniProt Related Accession:O75594
Molecular Weight:
NCBI Full Name:Peptidoglycan recognition protein 1
NCBI Synonym Full Names:peptidoglycan recognition protein 1
NCBI Official Symbol:PGLYRP1  
NCBI Official Synonym Symbols:PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L  
NCBI Protein Information:peptidoglycan recognition protein 1; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein)
UniProt Protein Name:Peptidoglycan recognition protein 1
UniProt Synonym Protein Names:Peptidoglycan recognition protein short; PGRP-S
Protein Family:Peptidoglycan recognition protein
UniProt Gene Name:PGLYRP1  
UniProt Entry Name:PGRP1_HUMAN
Anti-PGLYRP1 Antibody (CAB10460)Western blot analysis of extracts of various cell lines, using PGLYRP1 antibody (CAB10460) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
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