Metabolism Antibodies 2
Anti-PGD Antibody (CAB7710)
- SKU:
- CAB7710
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PGD Antibody |
| Antibody SKU: | CAB7710 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 184-483 of human PGD (NP_002622.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A-549, 293T, Raji, Mouse kidney, Mouse lung, Mouse spleen, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 184-483 of human PGD (NP_002622.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KMVH NGIE YGDM QLIC EAYH LMKD VLGM AQDE MAQA FEDW NKTE LDSF LIEI TANI LKFQ DTDG KHLL PKIR DSAG QKGT GKWT AISA LEYG VPVT LIGE AVFA RCLS SLKD ERIQ ASKK LKGP QKFQ FDGD KKSF LEDI RKAL YASK IISY AQGF MLLR QAAT EFGW TLNY GGIA LMWR GGCI IRSV FLGK IKDA FDRN PELQ NLLL DDFF KSAV ENCQ DSWR RAVS TGVQ AGIP MPCF TTAL SFYD GYRH EMLP ASLI QAQR DYFG AHTY ELLA KPGQ FIHT NWTG HGGT VSSS SYNA |
| Gene ID: | 5226 |
| Uniprot: | P52209 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 51kDa/53kDa |
| Observed MW: | 46kDa |
| Synonyms: | PGD, 6PGD |
| Background: | 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Oxidoreductase; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytosol; nucleus Molecular Function:phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process |
| NCBI Summary: | 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P52209 |
| NCBI GenInfo Identifier: | 40068518 |
| NCBI Gene ID: | 5226 |
| NCBI Accession: | NP_002622.2 |
| UniProt Secondary Accession: | P52209,Q9BWD8, A8K2Y9, B4DQJ8, |
| UniProt Related Accession: | P52209 |
| Molecular Weight: | 51,872 Da |
| NCBI Full Name: | 6-phosphogluconate dehydrogenase, decarboxylating isoform 1 |
| NCBI Synonym Full Names: | phosphogluconate dehydrogenase |
| NCBI Official Symbol: | PGD |
| NCBI Official Synonym Symbols: | 6PGD |
| NCBI Protein Information: | 6-phosphogluconate dehydrogenase, decarboxylating |
| UniProt Protein Name: | 6-phosphogluconate dehydrogenase, decarboxylating |
| UniProt Gene Name: | PGD |
| UniProt Entry Name: | 6PGD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PGD antibody (CAB7710) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded Rat kidney using PGD antibody (CAB7710) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Human mammary cancer using PGD antibody (CAB7710) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse heart using PGD antibody (CAB7710) at dilution of 1:100 (40x lens). |
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