Anti-PGD Antibody (CAB0563)
- SKU:
- CAB0563
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PGD
- Synonyms:
- 6PGD
- Synonyms:
- phosphogluconate dehydrogenase
- Research Area:
- Metabolism
Description
| Product Name: | PGD Rabbit mAb |
| Product Code: | CAB0563 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | PGD, 6PGD, phosphogluconate dehydrogenase |
| Applications: | WB, IF, IP |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PGD. |
| Applications: | WB, IF, IP |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, HepG2, Jurkat, Mouse lung, Mouse liver, Mouse spleen, Rat lung, Rat liver, Rat kidney |
| Immunogen: | A synthesized peptide derived from human PGD. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5226 |
| Uniprot: | P52209 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 45kDa |
| Observed MW: | 49KDa |
| UniProt Protein Function: | PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Oxidoreductase; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: 1p36.22 Cellular Component: cytosol; nucleus Molecular Function:phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process |
| NCBI Summary: | 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015] |
| UniProt Code: | P52209 |
| NCBI GenInfo Identifier: | 40068518 |
| NCBI Gene ID: | 5226 |
| NCBI Accession: | NP_002622.2 |
| UniProt Secondary Accession: | P52209,Q9BWD8, A8K2Y9, B4DQJ8, |
| UniProt Related Accession: | P52209 |
| Molecular Weight: | 51,872 Da |
| NCBI Full Name: | 6-phosphogluconate dehydrogenase, decarboxylating isoform 1 |
| NCBI Synonym Full Names: | phosphogluconate dehydrogenase |
| NCBI Official Symbol: | PGD |
| NCBI Official Synonym Symbols: | 6PGD |
| NCBI Protein Information: | 6-phosphogluconate dehydrogenase, decarboxylating |
| UniProt Protein Name: | 6-phosphogluconate dehydrogenase, decarboxylating |
| UniProt Gene Name: | PGD |
| UniProt Entry Name: | 6PGD_HUMAN |
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