| NCBI Summary: | The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q86YN6 |
| NCBI GenInfo Identifier: | 289577090 |
| NCBI Gene ID: | 133522 |
| NCBI Accession: | NP_001166169.1 |
| UniProt Related Accession: | Q86YN6 |
| Molecular Weight: | 113kDa |
| NCBI Full Name: | peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 2 |
| NCBI Synonym Full Names: | PPARG coactivator 1 beta |
| NCBI Official Symbol: | PPARGC1B |
| NCBI Official Synonym Symbols: | PERC; ERRL1; PGC1B; PGC-1(beta) |
| NCBI Protein Information: | peroxisome proliferator-activated receptor gamma coactivator 1-beta |
| UniProt Protein Name: | Peroxisome proliferator-activated receptor gamma coactivator 1-beta |
| UniProt Synonym Protein Names: | PGC-1-related estrogen receptor alpha coactivator |
| UniProt Gene Name: | PPARGC1B |
| UniProt Entry Name: | PRGC2_HUMAN |
