Metabolism Antibodies 3

Anti-PGAM1 Antibody (CAB4170)

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SKU:
CAB4170
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

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Antibody Name:Anti-PGAM1 Antibody
Antibody SKU:CAB4170
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PGAM1
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, U-251MG, Mouse liver, Mouse brain, Mouse kidney, Rat brain, Rat spleen, Rat kidney
Immunogen:A synthesized peptide derived from human PGAM1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5223
Uniprot:P18669
Cellular Location:
Calculated MW:29kDa
Observed MW:28KDa
Synonyms:HEL-S-35, PGAM-B, PGAMA
Background:The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
UniProt Protein Function:PGAM1: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. Homodimer. In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
UniProt Protein Details:

Protein type:EC 5.4.2.4; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase; EC 3.1.3.13; Phosphatase (non-protein); EC 5.4.2.11

Chromosomal Location of Human Ortholog: 10q25.3

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function:protein binding; phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity; protein kinase binding

Biological Process: respiratory burst; glycolysis; dephosphorylation; regulation of glycolysis; carbohydrate metabolic process; glucose metabolic process; pathogenesis; regulation of pentose-phosphate shunt; gluconeogenesis

NCBI Summary:Phosphoglyceric acid mutase (EC 2.7.5.3) is widely distributed in mammalian tissues where it catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway (summary by Chen et al., 1974 [PubMed 4811757]).[supplied by OMIM, Nov 2010]
UniProt Code:P18669
NCBI GenInfo Identifier:130348
NCBI Gene ID:5223
NCBI Accession:P18669.2
UniProt Secondary Accession:P18669,Q9BWC0,
UniProt Related Accession:P18669
Molecular Weight:254
NCBI Full Name:Phosphoglycerate mutase 1
NCBI Synonym Full Names:phosphoglycerate mutase 1 (brain)
NCBI Official Symbol:PGAM1  
NCBI Official Synonym Symbols:PGAMA; PGAM-B; HEL-S-35  
NCBI Protein Information:phosphoglycerate mutase 1; BPG-dependent PGAM 1; phosphoglycerate mutase isozyme B; epididymis secretory protein Li 35; phosphoglycerate mutase A, nonmuscle form
UniProt Protein Name:Phosphoglycerate mutase 1
UniProt Synonym Protein Names:BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B
Protein Family:Phosphoglycerate mutase
UniProt Gene Name:PGAM1  
UniProt Entry Name:PGAM1_HUMAN
Anti-PGAM1 Antibody (CAB4170)Western blot - PGAM1 Rabbit mAb (CAB4170)
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