Cell Biology Antibodies 7
Anti-PFKFB4 Antibody (CAB17915)
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- SKU:
- CAB17915
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PFKFB4 Antibody |
| Antibody SKU: | CAB17915 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human PFKFB4 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human PFKFB4 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5210 |
| Uniprot: | Q16877 |
| Cellular Location: | |
| Calculated MW: | 49kDa/50kDa/54kDa |
| Observed MW: | Refer to figures |
| Synonyms: | PFKFB4 |
| Background: | The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2, 6-bisphosphate (F2, 6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2, 6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PFKFB4: Synthesis and degradation of fructose 2,6-bisphosphate. |
| UniProt Protein Details: | Protein type:EC 3.1.3.46; Motility/polarity/chemotaxis; EC 2.7.1.105; Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose; Kinase, other Chromosomal Location of Human Ortholog: 3p22-p21 Cellular Component: cytosol Molecular Function:6-phosphofructo-2-kinase activity |
| NCBI Summary: | The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q16877 |
| NCBI GenInfo Identifier: | 6226609 |
| NCBI Gene ID: | 5210 |
| NCBI Accession: | Q16877.6 |
| UniProt Secondary Accession: | Q16877,Q5S3G5, Q5XLC2, Q64EX5, |
| UniProt Related Accession: | Q16877 |
| Molecular Weight: | 50,203 Da |
| NCBI Full Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
| NCBI Synonym Full Names: | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 |
| NCBI Official Symbol: | PFKFB4 |
| NCBI Protein Information: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
| UniProt Protein Name: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
| UniProt Synonym Protein Names: | 6PF-2-K/Fru-2,6-P2ase testis-type isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46) |
| Protein Family: | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase |
| UniProt Gene Name: | PFKFB4 |
| UniProt Entry Name: | F264_HUMAN |
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