Anti-PFDN5 Antibody (CAB4101)
- SKU:
- CAB4101
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MM-1
- Synonyms:
- MM1
- Synonyms:
- PFD5
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Product Name: | PFDN5 Rabbit mAb |
| Product Code: | CAB4101 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MM-1, MM1, PFD5 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PFDN5 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BxPC-3, RD, Jurkat, Mouse lung, Mouse testis, Mouse spleen, Rat lung, Rat testis, Rat spleen |
| Immunogen: | A synthesized peptide derived from human PFDN5 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5204 |
| Uniprot: | Q99471 |
| Calculated MW: | 17kDa |
| Observed MW: | 17KDa |
| UniProt Protein Function: | PFDN5: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. Belongs to the prefoldin subunit alpha family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 12q12 Cellular Component: cytoplasm; nucleus; prefoldin complex Molecular Function:protein binding; unfolded protein binding; transcription corepressor activity Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; regulation of transcription, DNA-dependent; protein folding; retina development in camera-type eye; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99471 |
| NCBI GenInfo Identifier: | 12231038 |
| NCBI Gene ID: | 5204 |
| NCBI Accession: | Q99471.2 |
| UniProt Related Accession: | Q99471 |
| Molecular Weight: | 17kDa |
| NCBI Full Name: | Prefoldin subunit 5 |
| NCBI Synonym Full Names: | prefoldin subunit 5 |
| NCBI Official Symbol: | PFDN5 |
| NCBI Official Synonym Symbols: | MM1; MM-1; PFD5 |
| NCBI Protein Information: | prefoldin subunit 5 |
| UniProt Protein Name: | Prefoldin subunit 5 |
| UniProt Synonym Protein Names: | C-Myc-binding protein Mm-1; Myc modulator 1 |
| Protein Family: | Prefoldin |
| UniProt Gene Name: | PFDN5 |
| UniProt Entry Name: | PFD5_HUMAN |
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