Cell Biology Antibodies 17

Anti-Peroxiredoxin 4 Antibody (CAB9131)

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SKU:
CAB9131
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-Peroxiredoxin 4 Antibody
Antibody SKU:CAB9131
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human Peroxiredoxin 4
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Jurkat, U-251MG, Mouse liver, Rat lung
Immunogen:A synthesized peptide derived from human Peroxiredoxin 4
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10549
Uniprot:Q13162
Cellular Location:
Calculated MW:27kDa
Observed MW:27KDa
Synonyms:AOE37-2, AOE372, HEL-S-97n, PRX-4
Background: The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Protein Function:PRDX4: Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Belongs to the AhpC/TSA family.
UniProt Protein Details:

Protein type:Oxidoreductase; EC 1.11.1.15; Secreted; Mitochondrial; Secreted, signal peptide

Chromosomal Location of Human Ortholog: Xp22.11

Cellular Component: cytosol; extracellular space; mitochondrion; nucleus; smooth endoplasmic reticulum

Molecular Function:protein binding; protein homodimerization activity; thioredoxin peroxidase activity

Biological Process: 4-hydroxyproline metabolic process; cell redox homeostasis; extracellular matrix organization and biogenesis; I-kappaB phosphorylation; male gonad development; protein maturation via protein folding; spermatogenesis

NCBI Summary:The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Code:Q13162
NCBI GenInfo Identifier:3024727
NCBI Gene ID:10549
NCBI Accession:Q13162.1
UniProt Secondary Accession:Q13162,Q6FHT3,
UniProt Related Accession:Q13162
Molecular Weight:
NCBI Full Name:Peroxiredoxin-4
NCBI Synonym Full Names:peroxiredoxin 4
NCBI Official Symbol:PRDX4  
NCBI Official Synonym Symbols:PRX-4; AOE372; AOE37-2; HEL-S-97n  
NCBI Protein Information:peroxiredoxin-4
UniProt Protein Name:Peroxiredoxin-4
UniProt Synonym Protein Names:Antioxidant enzyme AOE372; AOE37-2; Peroxiredoxin IV; Prx-IV; Thioredoxin peroxidase AO372; Thioredoxin-dependent peroxide reductase A0372
Protein Family:Peroxiredoxin
UniProt Gene Name:PRDX4  
UniProt Entry Name:PRDX4_HUMAN
Anti-Peroxiredoxin 4 Antibody (CAB9131)Western blot - Peroxiredoxin 4 Rabbit mAb (CAB9131)
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