Anti-PEN2/PSENEN Antibody (CAB8678)

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SKU:
CAB8678
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MDS033
Synonyms:
MSTP064
Synonyms:
PEN-2
Synonyms:
PEN2

Description

Product Name:PEN2/PSENEN Rabbit mAb
Product Code:CAB8678
Size:20uL, 50uL, 100uL
Synonyms:MDS033, MSTP064, PEN-2, PEN2
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PEN2/PSENEN
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, A-549, SH-SY5Y, Mouse kidney, Rat lung
Immunogen:A synthesized peptide derived from human PEN2/PSENEN
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:55851
Uniprot:Q9NZ42
Calculated MW:13kDa
Observed MW:14kDa
UniProt Protein Function:PSENEN: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PSENEN/PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Belongs to the PEN-2 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.12

Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: positive regulation of catalytic activity; axon guidance; Notch signaling pathway; amyloid precursor protein catabolic process; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; membrane protein ectodomain proteolysis; ephrin receptor signaling pathway; Notch receptor processing; protein processing

Disease: Acne Inversa, Familial, 2

NCBI Summary:Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:Q9NZ42
NCBI GenInfo Identifier:28144920
NCBI Gene ID:55851
NCBI Accession:NP_758844
UniProt Related Accession:Q9NZ42
Molecular Weight:~ 12kDa
NCBI Full Name:gamma-secretase subunit PEN-2
NCBI Synonym Full Names:presenilin enhancer, gamma-secretase subunit
NCBI Official Symbol:PSENEN  
NCBI Official Synonym Symbols:PEN2; PEN-2; MDS033; ACNINV2; MSTP064  
NCBI Protein Information:gamma-secretase subunit PEN-2
UniProt Protein Name:Gamma-secretase subunit PEN-2
UniProt Synonym Protein Names:Presenilin enhancer protein 2
UniProt Gene Name:PSENEN  
UniProt Entry Name:PEN2_HUMAN
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