Signal Transduction Antibodies 3

Anti-PELI1 Antibody (CAB8240)

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SKU:
CAB8240
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:PELI1 Rabbit Polyclonal Antibody
Antibody SKU:CAB8240
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PELI1 (NP_065702.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PELI1 (NP_065702.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFSP DQEN HPSK APVK YGEL IVLG YNGS LPNG DRGR RKSR FALF KRPK ANGV KPST VHIA CTPQ AAKA ISNK DQHS ISYT LSRA QTVV VEYT HDSN TDMF QIGR STES PIDF VVTD TVPG SQSN SDTQ SVQS TISR FACR IICE RNPP FTAR IYAA GFDS SKNI FLGE KAAK WKTS DGQM DGLT TNGV LVMH PRNG FTED SKPG IWRE ISVC GNVF SLRE TRSA QQRG KMVE IETN QLQD GSLI DLCG AT
Gene ID:57162
Uniprot:Q96FA3
Cellular Location:
Calculated MW:46kDa
Observed MW:46kDa
Synonyms:PELI1
Background:
UniProt Protein Function:PELI1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Found in a complex containing TRAF6, IRAK1 and IRAK4. Interacts with MAP3K7. Belongs to the pellino family.
UniProt Protein Details:

Protein type:Ligase; Ubiquitin ligase; Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cytosol

Molecular Function:protein binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade

UniProt Code:Q96FA3
NCBI GenInfo Identifier:37999756
NCBI Gene ID:57162
NCBI Accession:Q96FA3.2
UniProt Secondary Accession:Q96FA3,Q96SM0, Q9GZY5, Q9HCX0,
UniProt Related Accession:Q96FA3
Molecular Weight:46,286 Da
NCBI Full Name:E3 ubiquitin-protein ligase pellino homolog 1
NCBI Synonym Full Names:pellino E3 ubiquitin protein ligase 1
NCBI Official Symbol:PELI1  
NCBI Protein Information:E3 ubiquitin-protein ligase pellino homolog 1
UniProt Protein Name:E3 ubiquitin-protein ligase pellino homolog 1
UniProt Synonym Protein Names:Pellino-related intracellular-signaling molecule
Protein Family:E3 ubiquitin-protein ligase
UniProt Gene Name:PELI1  
UniProt Entry Name:PELI1_HUMAN
Anti-PELI1 Polyclonal Antibody (CAB8240)Western blot analysis of extracts of rat brain, using PELI1 antibody (CAB8240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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