Cell Biology Antibodies 17

Anti-PEDF Antibody (CAB3475)

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SKU:
CAB3475
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PEDF Antibody
Antibody SKU:CAB3475
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PEDF
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Rat liver, Human plasma, Mouse liver
Immunogen:A synthesized peptide derived from human PEDF
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5176
Uniprot:P36955
Cellular Location:
Calculated MW:46kDa
Observed MW:46KDa
Synonyms:EPC-1, OI12, OI6, PEDF, PIG35
Background:This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]
UniProt Protein Function:PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; extracellular region; melanosome; basement membrane

Molecular Function:serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; retina development in camera-type eye; short-term memory; response to arsenic; multicellular organismal development; negative regulation of inflammatory response; response to acidity; kidney development; aging

Disease: Osteogenesis Imperfecta, Type Vi

NCBI Summary:The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
UniProt Code:P36955
NCBI GenInfo Identifier:313104314
NCBI Gene ID:5176
NCBI Accession:P36955.4
UniProt Secondary Accession:P36955,Q13236, Q2TU83, Q96CT1, Q96R01, Q9BWA4, F1T092
UniProt Related Accession:P36955
Molecular Weight:46,312 Da
NCBI Full Name:Pigment epithelium-derived factor
NCBI Synonym Full Names:serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
NCBI Official Symbol:SERPINF1  
NCBI Official Synonym Symbols:OI6; OI12; PEDF; EPC-1; PIG35  
NCBI Protein Information:pigment epithelium-derived factor; serpin F1; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
UniProt Protein Name:Pigment epithelium-derived factor
UniProt Synonym Protein Names:Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
UniProt Gene Name:SERPINF1  
UniProt Entry Name:PEDF_HUMAN
Anti-PEDF Antibody (CAB3475)Western blot - PEDF Rabbit mAb (CAB3475)
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