Epigenetics & Nuclear Signaling Antibodies 2
Anti-Pea3 / ETV4 Antibody (CAB5797)
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- SKU:
- CAB5797
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-Pea3 / ETV4 Antibody |
| Antibody SKU: | CAB5797 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human Pea3 / ETV4 (NP_001248368.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, Mouse stomach, Mouse heart, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human Pea3 / ETV4 (NP_001248368.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MYLH TEGF SGPS PGDG AMGY GYEK PLRP FPDD VCVV PEKF EGDI KQEG VGAF REGP PYQR RGAL QLWQ FLVA LLDD PTNA HFIA WTGR GMEF KLIE PEEV ARLW GIQK NRPA MNYD KLSR SLRY YYEK GIMQ KVAG ERYV YKFV CEPE ALFS LAFP DNQR PALK AEFD RPVS EEDT VPLS HLDE SPAY LPEL AGPA QPFG PKGG YSY |
| Gene ID: | 2118 |
| Uniprot: | P43268 |
| Cellular Location: | Nucleus |
| Calculated MW: | 23kDa/49kDa/53kDa |
| Observed MW: | 54KDa |
| Synonyms: | ETV4, E1A-F, E1AF, PEA3, PEAS3, ETS variant 4, Pea3/ETV4 |
| Background: |
| UniProt Protein Function: | ETV4: Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. Belongs to the ETS family. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 17q21 Cellular Component: nucleolus Molecular Function:protein binding Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; motor axon guidance; stem cell differentiation; cell differentiation; negative regulation of mammary gland epithelial cell proliferation |
| UniProt Code: | P43268 |
| NCBI GenInfo Identifier: | 62512145 |
| NCBI Gene ID: | 2118 |
| NCBI Accession: | P43268.3 |
| UniProt Secondary Accession: | P43268,Q96AW9, A8K314, B7Z5J3, B7Z9J6, |
| UniProt Related Accession: | P43268 |
| Molecular Weight: | 484 |
| NCBI Full Name: | ETS translocation variant 4 |
| NCBI Synonym Full Names: | ets variant 4 |
| NCBI Official Symbol: | ETV4 |
| NCBI Official Synonym Symbols: | E1AF; PEA3; E1A-F; PEAS3 |
| NCBI Protein Information: | ETS translocation variant 4; adenovirus E1A enhancer-binding protein; polyomavirus enhancer activator 3 homolog; EWS protein/E1A enhancer binding protein chimera; ets variant gene 4 (E1A enhancer-binding protein, E1AF) |
| UniProt Protein Name: | ETS translocation variant 4 |
| UniProt Synonym Protein Names: | Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3 |
| Protein Family: | ETS translocation |
| UniProt Gene Name: | ETV4 |
| UniProt Entry Name: | ETV4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using Pea3 / ETV4 Rabbit pAb (CAB5797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded Human skin using Pea3 / ETV4 antibody (CAB5797) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Mouse skin using Pea3 / ETV4 antibody (CAB5797) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat skin using Pea3 / ETV4 antibody (CAB5797) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U-2 OS cells using Pea3 / ETV4 Rabbit pAb (CAB5797) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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