Name: Anti-PDLIM7 Antibody (CAB17942)
Brand: Cell Biology Antibodies 14
SKU: CAB17942
Availability: OutOfStock

Antibody Name:	Anti-PDLIM7 Antibody
Antibody SKU:	CAB17942
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of human PDLIM7 (NP_998801.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:	Jurkat, Mouse lung

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of human PDLIM7 (NP_998801.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	KPQK ASAP AADP PRYT FAPS VSLN KTAR PFGA PPPA DSAP QQNG QPLR PLVP DASK QRLM ENTE DWRP RPGT GQSR SFRI LAHL TGTE FMQD PDEE HLKK S
Gene ID:	9260
Uniprot:	Q9NR12
Cellular Location:
Calculated MW:	50kDa
Observed MW:	50kDa

Western blot - PDLIM7 Polyclonal Antibody (CAB17942)

Synonyms:	LMP1, LMP3, PDLIM7
Background:

UniProt Protein Function:	PDLIM7: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation e.g (embryonic flat bones mandible and cranium), and endochondral bone formation e.g (embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 5q35.3 Cellular Component: ruffle; focal adhesion; cytoplasm; stress fiber; nucleus; actin cytoskeleton Molecular Function:protein binding; zinc ion binding Biological Process: receptor-mediated endocytosis; positive regulation of osteoblast differentiation; ossification; multicellular organismal development; cell differentiation; actin cytoskeleton organization and biogenesis
NCBI Summary:	The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9NR12
NCBI GenInfo Identifier:	74752914
NCBI Gene ID:	9260
NCBI Accession:	Q9NR12.1
UniProt Related Accession:	Q9NR12
Molecular Weight:	50kDa
NCBI Full Name:	PDZ and LIM domain protein 7
NCBI Synonym Full Names:	PDZ and LIM domain 7
NCBI Official Symbol:	PDLIM7
NCBI Official Synonym Symbols:	LMP1; LMP3
NCBI Protein Information:	PDZ and LIM domain protein 7
UniProt Protein Name:	PDZ and LIM domain protein 7
UniProt Synonym Protein Names:	LIM mineralization protein; LMP; Protein enigma
Protein Family:	PDZ and LIM domain protein
UniProt Gene Name:	PDLIM7
UniProt Entry Name:	PDLI7_HUMAN