Cell Biology Antibodies 17

Anti-PDIA6 Antibody (CAB4260)

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SKU:
CAB4260
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PDIA6 Antibody
Antibody SKU:CAB4260
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human PDIA6
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, HepG2, Mouse liver, Rat liver
Immunogen:A synthesized peptide derived from human PDIA6
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10130
Uniprot:Q15084
Cellular Location:
Calculated MW:48kDa
Observed MW:54KDa
Synonyms:ERP5, P5, TXNDC7
Background:This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
UniProt Protein Function:PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 5.3.4.1; Isomerase

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; plasma membrane; ER-Golgi intermediate compartment

Molecular Function:protein binding; protein disulfide isomerase activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; cell redox homeostasis; apoptotic cell clearance

NCBI Summary:Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM, Mar 2008]
UniProt Code:Q15084
NCBI GenInfo Identifier:2501205
NCBI Gene ID:10130
NCBI Accession:Q15084.1
UniProt Secondary Accession:Q15084,Q53RC7, Q6ZSH5, Q99778, B3KY95, B5MCQ5, B7Z254 B7Z4M8, F8WA83,
UniProt Related Accession:Q15084
Molecular Weight:440
NCBI Full Name:Protein disulfide-isomerase A6
NCBI Synonym Full Names:protein disulfide isomerase family A, member 6
NCBI Official Symbol:PDIA6  
NCBI Official Synonym Symbols:P5; ERP5; TXNDC7  
NCBI Protein Information:protein disulfide-isomerase A6; ER protein 5; protein disulfide isomerase P5; endoplasmic reticulum protein 5; thioredoxin domain-containing protein 7; protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; thioredoxin doma
UniProt Protein Name:Protein disulfide-isomerase A6
UniProt Synonym Protein Names:Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7
Protein Family:Protein disulfide-isomerase
UniProt Gene Name:PDIA6  
UniProt Entry Name:PDIA6_HUMAN
Anti-PDIA6 Antibody (CAB4260)Western blot - PDIA6 Rabbit mAb (CAB4260)
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