Cell Biology Antibodies 12

Anti-PDGFRL Antibody (CAB9169)

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SKU:
CAB9169
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PDGFRL Antibody
Antibody SKU:CAB9169
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 15-205 of human PDGFRL (NP_006198.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NCI-H125, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 15-205 of human PDGFRL (NP_006198.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ALED VTGQ HLPK NKRP KEPG ENRI KPTN KKVK PKIP KMKD RDSA NSAP KTQS IMMQ VLDK GRFQ KPAA TLSL LAGQ TVEL RCKG SRIG WSYP AYLD TFKD SRLS VKQN ERYG QLTL VNST SADT GEFS CWVQ LCSG YICR KDEA KTGS TYIF FTEK GELF VPSP SYFD VVYL NPDR QAVV PCRV TVLS AKV
Gene ID:5157
Uniprot:Q15198
Cellular Location:Secreted
Calculated MW:41kDa
Observed MW:42kDa
Synonyms:PDGFRL, PDGRL, PRLTS
Background:This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.
UniProt Protein Function:PDGFRL: Defects in PDGFRL are associated with colorectal cancer (CRC).
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Receptor, misc.

Chromosomal Location of Human Ortholog: 8p22-p21.3

Molecular Function:platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity

Disease: Hepatocellular Carcinoma

NCBI Summary:This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]
UniProt Code:Q15198
NCBI GenInfo Identifier:74762141
NCBI Gene ID:5157
NCBI Accession:Q15198.1
UniProt Secondary Accession:Q15198,Q6FH04, A8K085,
UniProt Related Accession:Q15198
Molecular Weight:41,861 Da
NCBI Full Name:Platelet-derived growth factor receptor-like protein
NCBI Synonym Full Names:platelet derived growth factor receptor like
NCBI Official Symbol:PDGFRL  
NCBI Official Synonym Symbols:PDGRL; PRLTS  
NCBI Protein Information:platelet-derived growth factor receptor-like protein
UniProt Protein Name:Platelet-derived growth factor receptor-like protein
UniProt Synonym Protein Names:PDGF receptor beta-like tumor suppressor
Protein Family:Platelet-derived growth factor receptor-like protein
UniProt Gene Name:PDGFRL  
UniProt Entry Name:PGFRL_HUMAN
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