Cell Biology Antibodies 12
Anti-PDGFD Antibody (CAB8263)
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- SKU:
- CAB8263
- Product Type:
- Antibody
- Applications:
- WB
- Applications:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | PDGFD Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8263 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 185-364 of human PDGFD (NP_149126.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, THP-1, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 185-364 of human PDGFD (NP_149126.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SGVS YNSP SVTD PTLI ADAL DKKI AEFD TVED LLKY FNPE SWQE DLEN MYLD TPRY RGRS YHDR KSKV DLDR LNDD AKRY SCTP RNYS VNIR EELK LANV VFFP RCLL VQRC GGNC GCGT VNWR SCTC NSGK TVKK YHEV LQFE PGHI KRRG RAKT MALV DIQL DHHE RCDC ICSS RPPR |
| Gene ID: | 80310 |
| Uniprot: | Q9GZP0 |
| Cellular Location: | Secreted |
| Calculated MW: | 42kDa |
| Observed MW: | 43kDa |
| Synonyms: | PDGFD, IEGF, MSTP036, SCDGF-B, SCDGFB |
| Background: | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. |
| UniProt Protein Function: | PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Oncoprotein Chromosomal Location of Human Ortholog: 11q22.3 Cellular Component: Golgi membrane; endoplasmic reticulum lumen; extracellular region Molecular Function:growth factor activity; platelet-derived growth factor receptor binding Biological Process: multicellular organismal development; positive regulation of cell division; platelet-derived growth factor receptor signaling pathway; regulation of peptidyl-tyrosine phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9GZP0 |
| NCBI GenInfo Identifier: | 13376808 |
| NCBI Gene ID: | 80310 |
| NCBI Accession: | NP_079484.1 |
| UniProt Secondary Accession: | Q9GZP0,Q9BWV5, A8K9T6, |
| UniProt Related Accession: | Q9GZP0 |
| Molecular Weight: | |
| NCBI Full Name: | platelet-derived growth factor D isoform 1 |
| NCBI Synonym Full Names: | platelet derived growth factor D |
| NCBI Official Symbol: | PDGFD |
| NCBI Official Synonym Symbols: | IEGF; SCDGFB; MSTP036; SCDGF-B |
| NCBI Protein Information: | platelet-derived growth factor D |
| UniProt Protein Name: | Platelet-derived growth factor D |
| UniProt Synonym Protein Names: | Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B |
| Protein Family: | Platelet-derived growth factor |
| UniProt Gene Name: | PDGFD |
| UniProt Entry Name: | PDGFD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDGFD antibody (CAB8263) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of U2OS cells using PDGFD antibody (CAB8263) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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