Cell Biology Antibodies 5

Anti-PDGFC Antibody (CAB15174)

(No reviews yet) Write a Review
SKU:
CAB15174
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-PDGFC Antibody
Antibody SKU:CAB15174
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 166-345 of human PDGFC (NP_057289.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, Mouse kidney, Mouse liver, Mouse heart, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 166-345 of human PDGFC (NP_057289.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QFTE AVSP SVLP PSAL PLDL LNNA ITAF STLE DLIR YLEP ERWQ LDLE DLYR PTWQ LLGK AFVF GRKS RVVD LNLL TEEV RLYS CTPR NFSV SIRE ELKR TDTI FWPG CLLV KRCG GNCA CCLH NCNE CQCV PSKV TKKY HEVL QLRP KTGV RGLH KSLT DVAL EHHE ECDC VCRG STGG
Gene ID:56034
Uniprot:Q9NRA1
Cellular Location:Cytoplasm, Cytoplasmic granule, Nucleus, Secreted
Calculated MW:18kDa/20kDa/31kDa/39kDa
Observed MW:40kDa
Synonyms:PDGFC, FALLOTEIN, SCDGF
Background:The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene.
UniProt Protein Function:PDGFC: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q32

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi membrane; plasma membrane

Molecular Function:platelet-derived growth factor receptor binding; protein binding; protein homodimerization activity

Biological Process: blood coagulation; central nervous system development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of DNA replication; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation

NCBI Summary:The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
UniProt Code:Q9NRA1
NCBI GenInfo Identifier:205830662
NCBI Gene ID:56034
NCBI Accession:Q9NRA1.2
UniProt Secondary Accession:Q9NRA1,Q4W5M9, Q9UL22, B4DU34, B9EGR8,
UniProt Related Accession:Q9NRA1
Molecular Weight:20,609 Da
NCBI Full Name:Platelet-derived growth factor C
NCBI Synonym Full Names:platelet derived growth factor C
NCBI Official Symbol:PDGFC  
NCBI Official Synonym Symbols:SCDGF; FALLOTEIN  
NCBI Protein Information:platelet-derived growth factor C
UniProt Protein Name:Platelet-derived growth factor C
UniProt Synonym Protein Names:Fallotein; Spinal cord-derived growth factor; SCDGF
Protein Family:Platelet-derived growth factor
UniProt Gene Name:PDGFC  
UniProt Entry Name:PDGFC_HUMAN
Anti-PDGFC Antibody (CAB15174)Western blot analysis of extracts of various cell lines, using PDGFC antibody (CAB15174) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
View AllClose

0 Reviews

View AllClose

Related Products