Cell Biology Antibodies 18
Anti-PDE8B Antibody (CAB18399)
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- SKU:
- CAB18399
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE8B Antibody |
| Antibody SKU: | CAB18399 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human PDE8B. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: |
| Immunogen: | Recombinant protein of human PDE8B. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 8622 |
| Uniprot: | O95263 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | ADSD, PPNAD3, PDE8B |
| Background: |
| UniProt Protein Function: | PDE8B: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. Defects in PDE8B are the cause of striatal degeneration autosomal dominant (ADSD). It is a movement disorder affecting the striatal part of the basal ganglia and characterized by bradykinesia, dysarthria and muscle rigidity. These symptoms resemble idiopathic Parkinson disease, but tremor is not present. Defects in PDE8B are the cause of primary pigmented nodular adrenocortical disease type 3 (PPNAD3). PPNAD3 is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.4.53; Phosphodiesterase; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; signal transducer activity; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activity Biological Process: cyclic nucleotide metabolic process; behavioral fear response; cAMP catabolic process; operant conditioning; two-component signal transduction system (phosphorelay); visual learning; neuromuscular process controlling balance; negative regulation of insulin secretion Disease: Striatal Degeneration, Autosomal Dominant; Pigmented Nodular Adrenocortical Disease, Primary, 3 |
| NCBI Summary: | The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] |
| UniProt Code: | O95263 |
| NCBI GenInfo Identifier: | 73909134 |
| NCBI Gene ID: | 8622 |
| NCBI Accession: | AAH47627.1 |
| UniProt Secondary Accession: | O95263,Q5J7V7, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0 Q8N3T2, |
| UniProt Related Accession: | O95263 |
| Molecular Weight: | 98,979 Da |
| NCBI Full Name: | PDE8B protein, partial |
| NCBI Synonym Full Names: | phosphodiesterase 8B |
| NCBI Official Symbol: | PDE8B |
| NCBI Official Synonym Symbols: | ADSD; PPNAD3 |
| NCBI Protein Information: | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; hsPDE8B; cell proliferation-inducing gene 22 protein; 3',5' cyclic nucleotide phosphodiesterase 8B |
| UniProt Protein Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 22 protein |
| Protein Family: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE8B |
| UniProt Entry Name: | PDE8B_HUMAN |
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