Cell Biology Antibodies 5
Anti-PDE7A Antibody (CAB15079)
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- SKU:
- CAB15079
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE7A Antibody |
| Antibody SKU: | CAB15079 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-456 of human PDE7A (NP_002594.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Jurkat, mouse testis, rat brain, rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-456 of human PDE7A (NP_002594.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELSK QWSE KVTE EFFH QGDI EKKY HLGV SPLC DRHT ESIA NIQI GFMT YLVE PLFT EWAR FSNT RLSQ TMLG HVGL NKAS WKGL QREQ SSSE DTDA AFEL NSQL LPQE NRLS |
| Gene ID: | 5150 |
| Uniprot: | Q13946 |
| Cellular Location: | Cytoplasm, cytosol |
| Calculated MW: | 48kDa/52kDa/55kDa |
| Observed MW: | 56kDa |
| Synonyms: | PDE7A, HCP1, PDE7 |
| Background: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.53 Chromosomal Location of Human Ortholog: 8q13 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q13946 |
| NCBI GenInfo Identifier: | 3182958 |
| NCBI Gene ID: | 5150 |
| NCBI Accession: | Q13946.2 |
| UniProt Secondary Accession: | Q13946,O15380, Q96T72, A0AVH6, A8K436, A8K9G5, |
| UniProt Related Accession: | Q13946 |
| Molecular Weight: | 48,828 Da |
| NCBI Full Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| NCBI Synonym Full Names: | phosphodiesterase 7A |
| NCBI Official Symbol: | PDE7A |
| NCBI Official Synonym Symbols: | HCP1; PDE7 |
| NCBI Protein Information: | high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| UniProt Protein Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
| UniProt Synonym Protein Names: | HCP1; TM22 |
| Protein Family: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE7A |
| UniProt Entry Name: | PDE7A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE7A antibody (CAB15079) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10. |
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