Cell Biology Antibodies 13
Anti-PDE6G Antibody (CAB17516)
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- SKU:
- CAB17516
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE6G Antibody |
| Antibody SKU: | CAB17516 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human PDE6G (NP_002593.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse eye, Rat spleen |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human PDE6G (NP_002593.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNLE PPKA EFRS ATRV AGGP VTPR KGPP KFKQ RQTR QFKS KPPK KGVQ GFGD DIPG MEGL GTDI TVIC PWEA FNHL ELHE LAQY GII |
| Gene ID: | 5148 |
| Uniprot: | P18545 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 13kDa |
 | Western blot - PDE6G Polyclonal Antibody (CAB17516) |
| Synonyms: | PDEG, RP57, PDE6G |
| Background: | This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009] |
| UniProt Protein Function: | PDE6G: inhibitory gamma subunit of the retinal photoreceptor type 6 cGMP phosphodiesterase (PDE-gamma). Phosphorylated by GRK2. Regulates EGFR dependent stimulation of ERK1/2. Forms a cellular complex with src. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. Participates in processes of transmission and amplification of the visual signal. |
| UniProt Protein Details: | Protein type:EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 17q25 Cellular Component: plasma membrane Molecular Function:enzyme inhibitor activity; protein binding Biological Process: regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; Wnt receptor signaling pathway, calcium modulating pathway Disease: Retinitis Pigmentosa; Retinitis Pigmentosa 57 |
| NCBI Summary: | This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P18545 |
| NCBI GenInfo Identifier: | 4505673 |
| NCBI Gene ID: | 5148 |
| NCBI Accession: | NP_002593.1 |
| UniProt Secondary Accession: | P18545,Q3KP63, Q7Z3U8, |
| UniProt Related Accession: | P18545 |
| Molecular Weight: | 9,643 Da |
| NCBI Full Name: | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| NCBI Synonym Full Names: | phosphodiesterase 6G |
| NCBI Official Symbol: | PDE6G |
| NCBI Official Synonym Symbols: | PDEG; RP57 |
| NCBI Protein Information: | retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| UniProt Protein Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| Protein Family: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE6G |
| UniProt Entry Name: | CNRG_HUMAN |
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