| UniProt Protein Function: | PDE4D: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Isoform 5, isoform N3 and isoform 12 bind GNB2L1 via their unique N-terminus. Binds ARRB2. Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. Inhibited by rolipram. Activated by phosphatidic acid. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 12 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 5q12 Cellular Component: Golgi apparatus; centrosome; myofibril; membrane; apical plasma membrane; voltage-gated calcium channel complex; cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; protein binding; enzyme binding; metal ion binding; ubiquitin protein ligase binding; beta-2 adrenergic receptor binding; drug binding; cAMP binding; SH3 domain binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; ATPase binding Biological Process: neutrophil chemotaxis; negative regulation of heart contraction; regulation of heart rate; positive regulation of smooth muscle cell proliferation; multicellular organism growth; cAMP catabolic process; negative regulation of peptidyl-serine phosphorylation; positive regulation of smooth muscle cell migration; T cell receptor signaling pathway; memory; positive regulation of interferon-gamma production; cAMP-mediated signaling; cellular protein complex assembly; smooth muscle contraction; positive regulation of interleukin-2 production; regulation of receptor activity; positive regulation of interleukin-5 production; regulation of G-protein coupled receptor protein signaling pathway; lung development; aging |
| NCBI Summary: | This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q08499 |
| NCBI GenInfo Identifier: | 12644392 |
| NCBI Gene ID: | 5144 |
| NCBI Accession: | Q08499.2 |
| UniProt Secondary Accession: | Q08499,O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84 Q8IVA9, Q8IVD2, Q8IVD3, Q96HL4, Q9HCX7, |
| UniProt Related Accession: | Q08499 |
| Molecular Weight: | 809 |
| NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
| NCBI Synonym Full Names: | phosphodiesterase 4D, cAMP-specific |
| NCBI Official Symbol: | PDE4D |
| NCBI Official Synonym Symbols: | DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2 |
| NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) |
| UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4D |
| UniProt Synonym Protein Names: | DPDE3; PDE43 |
| Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE4D |
| UniProt Entry Name: | PDE4D_HUMAN |
