Cell Biology Antibodies 3
Anti-PDE4C Antibody (CAB13038)
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- SKU:
- CAB13038
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE4C Antibody |
| Antibody SKU: | CAB13038 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 638-712 of human PDE4C (NP_000914.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IPRS PSDL TNPE RDGP DRFQ FELT LEEA EEED EEEE EEGE ETAL AKEA LELP DTEL LSPE AGPD PGDL PLDN QRT |
| Gene ID: | 5143 |
| Uniprot: | Q08493 |
| Cellular Location: | Cell projection, cilium |
| Calculated MW: | 67kDa/75kDa/79kDa |
| Observed MW: | Refer to Figures |
| Synonyms: | PDE4C, DPDE1, PDE21 |
| Background: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | PDE4C: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Phosphodiesterase; EC 3.1.4.53; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: cytosol; extracellular space Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity |
| NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | Q08493 |
| NCBI GenInfo Identifier: | 20141263 |
| NCBI Gene ID: | 5143 |
| NCBI Accession: | Q08493.2 |
| UniProt Secondary Accession: | Q08493,Q9UN44, Q9UN45, Q9UN46, Q9UPJ6, B3KTC4, |
| UniProt Related Accession: | Q08493 |
| Molecular Weight: | Da |
| NCBI Full Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
| NCBI Synonym Full Names: | phosphodiesterase 4C |
| NCBI Official Symbol: | PDE4C |
| NCBI Official Synonym Symbols: | DPDE1 |
| NCBI Protein Information: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
| UniProt Protein Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4C |
| UniProt Synonym Protein Names: | DPDE1; PDE21 |
| Protein Family: | cAMP-specific 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE4C |
| UniProt Entry Name: | PDE4C_HUMAN |
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