Cell Biology Antibodies 1

Anti-PDE4B Antibody (CAB10196)

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SKU:
CAB10196
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PDE4B Antibody
Antibody SKU:CAB10196
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PDE4B (NP_002591.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:3000
Reactivity:Human, Mouse
Positive Samples:U-87MG, A-549, HL-60, Mouse brain, Mouse lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human PDE4B (NP_002591.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKKS RSVM TVMA DDNV KDYF ECSL SKSY SSSS NTLG IDLW RGRR CCSG NLQL PPLS QRQS ERAR TPEG DGIS RPTT LPLT TLPS IAIT TVSQ ECFD VENG PSPG RSPL DPQA SSSA GLVL HATF PGHS QR
Gene ID:5142
Uniprot:Q07343
Cellular Location:
Calculated MW:57kDa/64kDa/82kDa/83kDa
Observed MW:83kDa
Synonyms:PDE4B, DPDE4, PDEIVB
Background:This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
UniProt Protein Function:Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
NCBI Summary:This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
UniProt Code:Q07343
NCBI GenInfo Identifier:729163
NCBI Gene ID:5142
NCBI Accession:Q07343.1
UniProt Secondary Accession:Q07343,O15443, Q13945, Q5TEK4, Q5TEK5, Q5TEK6, A5YW33
UniProt Related Accession:Q07343
Molecular Weight:57,709 Da
NCBI Full Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
NCBI Synonym Full Names:phosphodiesterase 4B
NCBI Official Symbol:PDE4B  
NCBI Official Synonym Symbols:DPDE4; PDEIVB  
NCBI Protein Information:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt Protein Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt Synonym Protein Names:DPDE4; PDE32
Protein Family:cAMP-specific 3',5'-cyclic phosphodiesterase
UniProt Gene Name:PDE4B  
UniProt Entry Name:PDE4B_HUMAN
Anti-PDE4B Antibody (CAB10196)Western blot analysis of extracts of various cell lines, using PDE4B antibody (CAB10196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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