Cell Biology Antibodies 15
Anti-PDE3A Antibody (CAB17919)
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- SKU:
- CAB17919
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE3A Antibody |
| Antibody SKU: | CAB17919 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-660 of human PDE3A (NP_000912.3). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, mouse lung, mouse heart, mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-660 of human PDE3A (NP_000912.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LLST QLTF QAIH KPRV NPVT SLSE NYTC SDSE ESSE KDKL AIPK RLRR SLPP GLLR RVSS TWTT TTSA TGLP TLEP APVR RDRS TSIK LQEA PSSS PDSW NNPV MMTL TKSR SFTS SYAI SAAN HVKA KKQS RPGA LAKI SPLS SPCS SPLQ GTPA SSLV SKIS AVQF PESA DTTA KQSL GSHR ALTY TQSA PDLS PQIL TPPV ICSS CGRP YSQG NPAD EPLE RSGV ATRT PSRT DDTA QVTS DYET NNNS DSSD IVQN EDET ECLR EPLR KASA CSTY A |
| Gene ID: | 5139 |
| Uniprot: | Q14432 |
| Cellular Location: | |
| Calculated MW: | 125kDa |
| Observed MW: | 125kDa |
 | Western blot - PDE3A Polyclonal Antibody (CAB17919) |
| Synonyms: | HTNB, CGI-PDE, CGI-PDE A, CGI-PDE-A, PDE3A |
| Background: | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | PDE3A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Inhibited by cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. |
| UniProt Protein Details: | Protein type:EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 12p12.2 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP-mediated signaling; lipid metabolic process; negative regulation of vascular permeability; positive regulation of vascular permeability Disease: Hypertension And Brachydactyly Syndrome |
| NCBI Summary: | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q14432 |
| NCBI GenInfo Identifier: | 347658967 |
| NCBI Gene ID: | 5139 |
| NCBI Accession: | NM_000921.4 |
| UniProt Secondary Accession: | Q14432,O60865, Q13348, Q17RD1, |
| UniProt Related Accession: | Q14432 |
| Molecular Weight: | ~84 kDa |
| NCBI Full Name: | Homo sapiens phosphodiesterase 3A (PDE3A), transcript variant 1, mRNA |
| NCBI Synonym Full Names: | phosphodiesterase 3A |
| NCBI Official Symbol: | PDE3A |
| NCBI Official Synonym Symbols: | HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A |
| NCBI Protein Information: | cGMP-inhibited 3',5'-cyclic phosphodiesterase A |
| UniProt Protein Name: | cGMP-inhibited 3',5'-cyclic phosphodiesterase A |
| UniProt Synonym Protein Names: | Cyclic GMP-inhibited phosphodiesterase A; CGI-PDE A |
| Protein Family: | cGMP-inhibited 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE3A |
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