| UniProt Protein Function: | PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.17; Mitochondrial Chromosomal Location of Human Ortholog: 11q13.4 Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; mitochondrial matrix; nucleus; perinuclear region of cytoplasm; plasma membrane; presynaptic membrane Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; calcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; drug binding; protein binding; protein homodimerization activity; TPR domain binding Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP catabolic process; cGMP-mediated signaling; metabolic process; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular permeability; positive regulation of inflammatory response; positive regulation of vascular permeability; protein targeting to mitochondrion |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O00408 |
| NCBI GenInfo Identifier: | 3182954 |
| NCBI Gene ID: | 5138 |
| NCBI Accession: | O00408.1 |
| UniProt Secondary Accession: | O00408,Q5J791, Q5J792, Q5J793, Q6ZMR1, B2R646, B3KRV5 E9PGI1, F6W5Z0 |
| UniProt Related Accession: | O00408 |
| Molecular Weight: | 87,235 Da |
| NCBI Full Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| NCBI Synonym Full Names: | phosphodiesterase 2A |
| NCBI Official Symbol: | PDE2A |
| NCBI Official Synonym Symbols: | PDE2A1; PED2A4; cGSPDE; CGS-PDE |
| NCBI Protein Information: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| UniProt Protein Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| UniProt Synonym Protein Names: | Cyclic GMP-stimulated phosphodiesterase; CGS-PDE; cGSPDE |
| Protein Family: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE2A |
| UniProt Entry Name: | PDE2A_HUMAN |
