Cell Biology Antibodies 5
Anti-PDE1C Antibody (CAB15078)
(No reviews yet)
Write a Review
- SKU:
- CAB15078
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE1C Antibody |
| Antibody SKU: | CAB15078 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, mouse heart, mouse brain, mouse testis, rat heart, rat brain, rat testis |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VEPT FTVL TDMT EKIV SPLI DETS QTGG TGQR RSSL NSIS SSDA KRSG VKTS GSEG SAPI NNSV ISVD YKSF KATW TEVV HINR ERWR AKVP KEEK AKKE AEEK ARLA AEEQ QKEM EAKS QAEE GASG KAEK KTSG ETKN QVNG TRAN KSDN PRGK NSKA EKSS GEQQ QNGD FKDG KNKT DKKD HSNI GNDS KKTD DSQE |
| Gene ID: | 5137 |
| Uniprot: | Q14123 |
| Cellular Location: | |
| Calculated MW: | 72kDa/80kDa/86kDa |
| Observed MW: | 81kDa |
| Synonyms: | PDE1C, Hcam3, cam-PDE 1C, hCam-3, cam-PDE1C |
| Background: | This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. |
| UniProt Protein Function: | PDE1C: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17 Chromosomal Location of Human Ortholog: 7p14.3 Cellular Component: cytosol Molecular Function:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity |
| NCBI Summary: | This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q14123 |
| NCBI GenInfo Identifier: | 2499445 |
| NCBI Gene ID: | 5137 |
| NCBI Accession: | Q14123.1 |
| UniProt Secondary Accession: | Q14123,Q14124, Q8NB10, B3KPC6, E9PE92, |
| UniProt Related Accession: | Q14123 |
| Molecular Weight: | 86,896 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| NCBI Synonym Full Names: | phosphodiesterase 1C |
| NCBI Official Symbol: | PDE1C |
| NCBI Official Synonym Symbols: | Hcam3; hCam-3; cam-PDE 1C |
| NCBI Protein Information: | calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| UniProt Protein Name: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C |
| UniProt Synonym Protein Names: | hCam-3 |
| Protein Family: | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase |
| UniProt Gene Name: | PDE1C |
| UniProt Entry Name: | PDE1C_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDE1C antibody (CAB15078) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose
Related Products
Human PDE1C Recombinant Protein (RPES4584)
system_update_altDatasheetHuman PDE1C Recombinant Protein PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosph
Human anti-EPO antibody(anti-Erythropoietin antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक