Cell Biology Antibodies 13
Anti-PDE12 Antibody (CAB17270)
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- SKU:
- CAB17270
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PDE12 Antibody |
| Antibody SKU: | CAB17270 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse thymus, Rat thymus |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVEK LSRA EAGS QTAA GAME RAVV RCVP SEPK LSLS FALA DGSH KNMQ RDQS EPLG RVLS RIAT NALK GHAK AAAA KKSR KSRP NASG GAAC SGPG PEPA VFCE PVVK LYYR EEAV AEDV LNVD AWQD GAVL QIGD VKYK VERN PPAF TELQ LPRY IMAG FPVC PKLS LEFG DPAS SLFR WYKE AKPG AAEP EVGV PSSL SPSS PSSS WTET DVEE RVYT PSNA DIGL RLKL HCTP GDGQ RFGH SREL ESVC VVEA GPGT CTFD HRHL YTKK VTED ALIR TVSY |
| Gene ID: | 201626 |
| Uniprot: | Q6L8Q7 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 67kDa |
 | Western blot - PDE12 Rabbit pAb (CAB17270) |
| Synonyms: | PDE12, 2-PDE |
| Background: |
| UniProt Protein Function: | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system. |
| UniProt Code: | Q6L8Q7 |
| NCBI GenInfo Identifier: | 189027129 |
| NCBI Gene ID: | 201626 |
| NCBI Accession: | NP_808881.3 |
| UniProt Related Accession: | Q6L8Q7 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | 2',5'-phosphodiesterase 12 isoform 1 |
| NCBI Synonym Full Names: | phosphodiesterase 12 |
| NCBI Official Symbol: | PDE12 |
| NCBI Official Synonym Symbols: | 2-PDE; 2'-PDE |
| NCBI Protein Information: | 2',5'-phosphodiesterase 12 |
| UniProt Protein Name: | 2',5'-phosphodiesterase 12 |
| UniProt Synonym Protein Names: | Mitochondrial deadenylase (EC:3.1.13.4) |
| Protein Family: | 2',5'-phosphodiesterase |
| UniProt Gene Name: | PDE12 |
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