Antibody Name:	Anti-PDE11A Antibody
Antibody SKU:	CAB16122
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	NNAF QAKS GSAL AQLY GTSA TLEH HHFN HAVM ILQS EGHN IFAN LSSK EYSD LMQL LKQS ILAT DLTL YFER RTEF FELV SKGE YDWN IKNH RDIF RSML MTAC DLGA VTKP WEIS RQVA ELVT SEFF EQGD RERL ELKL TPSA IFDR NRKD ELPR LQLE WIDS ICMP LYQA LVKV NVKL KPML DSVA TNRS KWEE LHQK RLLA STAS SSPA SVMV AKED RN
Gene ID:	50940
Uniprot:	Q9HCR9
Cellular Location:	Cytoplasm, cytosol
Calculated MW:	55kDa/65kDa/78kDa/104kDa
Observed MW:	Refer to figures

Synonyms:

PDE11A, PPNAD2

Background:

The 3', 5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3', 5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	PDE11A: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. Defects in PDE11A are the cause of primary pigmented nodular adrenocortical disease type 2 (PPNAD2). Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. PPNAD2 is characterized by adrenal glands with overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. PPNAD2 leads to Cushing syndrome. Belongs to the cyclic nucleotide phosphodiesterase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:EC 3.1.4.17; Phosphodiesterase; Nucleotide Metabolism - purine; Mitochondrial; EC 3.1.4.35 Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Disease: Pigmented Nodular Adrenocortical Disease, Primary, 2
NCBI Summary:	The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9HCR9
NCBI GenInfo Identifier:	296439264
NCBI Gene ID:	50940
NCBI Accession:	Q9HCR9.2
UniProt Secondary Accession:	Q9HCR9,Q14CD1, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45
UniProt Related Accession:	Q9HCR9
Molecular Weight:	55,700 Da
NCBI Full Name:	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
NCBI Synonym Full Names:	phosphodiesterase 11A
NCBI Official Symbol:	PDE11A
NCBI Official Synonym Symbols:	PPNAD2
NCBI Protein Information:	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
UniProt Protein Name:	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
UniProt Synonym Protein Names:	cAMP and cGMP phosphodiesterase 11A
Protein Family:	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
UniProt Gene Name:	PDE11A
UniProt Entry Name:	PDE11_HUMAN