Cell Death Antibodies 1
Anti-PDCD2 Antibody (CAB15299)
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- SKU:
- CAB15299
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-PDCD2 Antibody |
| Antibody SKU: | CAB15299 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-344 of human PDCD2 (NP_002589.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-344 of human PDCD2 (NP_002589.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAAA GARP VELG FAES APAW RLRS EQFP SKVG GRPA WLGA AGLP GPQA LACE LCGR PLSF LLQV YAPL PGRP DAFH RCIF LFCC REQP CCAG LRVF RNQL PRKN DFYS YEPP SENP PPET GESV CLQL KSGA HLCR VCGC LGPK TCSR CHKA YYCS KEHQ TLDW RLGH KQAC AQPD HLDH IIPD HNFL FPEF EIVI ETED EIMP EVVE KEDY SEII GSMG EALE EELD SMAK HESR EDKI FQKF KTQI ALEP EQIL RYGR GIAP IWIS GENI PQEK DIPD CPCG AKRI LEFQ VMPQ LLNY LKAD RLGK SIDW GILA VFTC AESC SLGT GYTE EFVW KQDV TDTP |
| Gene ID: | 5134 |
| Uniprot: | Q16342 |
| Cellular Location: | Nucleus |
| Calculated MW: | 21kDa/22kDa/25kDa/35kDa/38kDa |
| Observed MW: | 38kDa |
| Synonyms: | PDCD2, RP8, ZMYND7 |
| Background: | This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. |
| UniProt Protein Function: | PDCD2: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6q27 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; enzyme binding; DNA binding; metal ion binding Biological Process: caspase activation; apoptosis; positive regulation of apoptosis |
| NCBI Summary: | This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q16342 |
| NCBI GenInfo Identifier: | 14249983 |
| NCBI Gene ID: | 5134 |
| NCBI Accession: | AAH08378.1 |
| UniProt Secondary Accession: | Q16342,Q58HM9, Q58HN0, Q9UH12, E9PCU7, F5GYS7, |
| UniProt Related Accession: | Q16342 |
| Molecular Weight: | 21,299 Da |
| NCBI Full Name: | Programmed cell death 2 |
| NCBI Synonym Full Names: | programmed cell death 2 |
| NCBI Official Symbol: | PDCD2 |
| NCBI Official Synonym Symbols: | RP8; ZMYND7 |
| NCBI Protein Information: | programmed cell death protein 2; zinc finger protein Rp-8; zinc finger MYND domain-containing protein 7 |
| UniProt Protein Name: | Programmed cell death protein 2 |
| UniProt Synonym Protein Names: | Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8 |
| Protein Family: | Programmed cell death protein |
| UniProt Gene Name: | PDCD2 |
| UniProt Entry Name: | PDCD2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PDCD2 antibody (CAB15299) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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