Cell Biology Antibodies 18

Anti-PCSK4 Antibody (CAB18433)

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SKU:
CAB18433
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-PCSK4 Antibody
Antibody SKU:CAB18433
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human PCSK4.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant protein of human PCSK4.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:54760
Uniprot:Q6UW60
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:PC4, SPC5, PCSK4
Background:
UniProt Protein Function:PCSK4: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Protease; EC 3.4.21.-; Cell development/differentiation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to membrane; acrosomal membrane

Molecular Function:serine-type endopeptidase activity

Biological Process: binding of sperm to zona pellucida; acrosome reaction; proteolysis; sperm capacitation

NCBI Summary:This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]
UniProt Code:Q6UW60
NCBI GenInfo Identifier:296439263
NCBI Gene ID:54760
NCBI Accession:Q6UW60.2
UniProt Secondary Accession:Q6UW60,Q8IY88, Q9UF79,
UniProt Related Accession:Q6UW60
Molecular Weight:26,118 Da
NCBI Full Name:Proprotein convertase subtilisin/kexin type 4
NCBI Synonym Full Names:proprotein convertase subtilisin/kexin type 4
NCBI Official Symbol:PCSK4  
NCBI Official Synonym Symbols:PC4; SPC5  
NCBI Protein Information:proprotein convertase subtilisin/kexin type 4; PCSK4
UniProt Protein Name:Proprotein convertase subtilisin/kexin type 4
UniProt Synonym Protein Names:Proprotein convertase 4; PC4
Protein Family:Proprotein convertase subtilisin/kexin
UniProt Gene Name:PCSK4  
UniProt Entry Name:PCSK4_HUMAN
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