Cell Biology Antibodies 12
Anti-PCSK2 Antibody (CAB8644)
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- SKU:
- CAB8644
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PCSK2 Antibody |
| Antibody SKU: | CAB8644 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human PCSK2 (NP_002585.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, HL-60, Mouse brain, Mouse pancreas, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human PCSK2 (NP_002585.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MKGG CVSQ WKAA AGFL FCVM VFAS AERP VFTN HFLV ELHK GGED KARQ VAAE HGFG VRKL PFAE GLYH FYHN GLAK AKRR RSLH HKQQ LERD PRVK MALQ QEGF DRKK RGYR DINE IDIN MNDP LFTK QWYL INTG QADG TPGL DLNV AEAW ELGY TGKG VTIG IMDD GIDY LHPD LASN YNAE ASYD FSSN DPYP YPRY TDDW FNSH GTRC AGEV SAAA |
| Gene ID: | 5126 |
| Uniprot: | P16519 |
| Cellular Location: | Cytoplasmic vesicle, secretory vesicle |
| Calculated MW: | 66kDa/68kDa/70kDa |
| Observed MW: | 70kDa |
| Synonyms: | PCSK2, NEC 2, NEC-2, NEC2, PC2, SPC2 |
| Background: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | PCSK2: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.21.94 Chromosomal Location of Human Ortholog: 20p11.2 Cellular Component: extracellular space; transport vesicle; membrane; dendrite; perikaryon Molecular Function:protein binding; serine-type endopeptidase activity; protein complex binding Biological Process: insulin processing; nervous system development; protein autoprocessing; cellular protein metabolic process; proteolysis |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P16519 |
| NCBI GenInfo Identifier: | 13124785 |
| NCBI Gene ID: | 5126 |
| NCBI Accession: | P16519.2 |
| UniProt Secondary Accession: | P16519,P21661, P28841, |
| UniProt Related Accession: | P16519,AAB32656 |
| Molecular Weight: | |
| NCBI Full Name: | Neuroendocrine convertase 2 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 2 |
| NCBI Official Symbol: | PCSK2 |
| NCBI Official Synonym Symbols: | PC2; NEC2; SPC2; NEC 2; NEC-2 |
| NCBI Protein Information: | neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2 |
| UniProt Protein Name: | Neuroendocrine convertase 2 |
| UniProt Synonym Protein Names: | KEX2-like endoprotease 2; Prohormone convertase 2; Proprotein convertase 2; PC2 |
| Protein Family: | Putative envelope glycoprotein |
| UniProt Gene Name: | PCSK2 |
| UniProt Entry Name: | NEC2_HUMAN |
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