Cell Biology Antibodies 5
Anti-PCOLCE Antibody (CAB15298)
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- SKU:
- CAB15298
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-PCOLCE Antibody |
| Antibody SKU: | CAB15298 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-449 of human PCOLCE (NP_002584.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | U-251MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 170-449 of human PCOLCE (NP_002584.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LTTP NWPE SDYP PGIS CSWH IIAP PDQV IALT FEKF DLEP DTYC RYDS VSVF NGAV SDDS RRLG KFCG DAVP GSIS SEGN ELLV QFVS DLSV TADG FSAS YKTL PRGT AKEG QGPG PKRG TEPK VKLP PKSQ PPEK TEES PSAP DAPT CPKQ CRRT GTLQ SNFC ASSL VVTA TVKS MVRE PGEG LAVT VSLI GAYK TGGL DLPS PPTG ASLK FYVP CKQC PPMK KGVS YLLM GQVE ENRG PVLP PESF VVLH RPNQ DQIL TNLS KRKC PSQP VRAA ASQD |
| Gene ID: | 5118 |
| Uniprot: | Q15113 |
| Cellular Location: | Secreted |
| Calculated MW: | 47kDa |
| Observed MW: | 48kDa |
| Synonyms: | PCOLCE, PCPE, PCPE-1, PCPE1 |
| Background: | Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. |
| UniProt Protein Function: | Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. |
| NCBI Summary: | Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15113 |
| NCBI GenInfo Identifier: | 6919941 |
| NCBI Gene ID: | 5118 |
| NCBI Accession: | Q15113.2 |
| UniProt Secondary Accession: | Q15113,O14550, B2R9E1, |
| UniProt Related Accession: | Q15113 |
| Molecular Weight: | 47,972 Da |
| NCBI Full Name: | Procollagen C-endopeptidase enhancer 1 |
| NCBI Synonym Full Names: | procollagen C-endopeptidase enhancer |
| NCBI Official Symbol: | PCOLCE |
| NCBI Official Synonym Symbols: | PCPE; PCPE1; PCPE-1 |
| NCBI Protein Information: | procollagen C-endopeptidase enhancer 1 |
| UniProt Protein Name: | Procollagen C-endopeptidase enhancer 1 |
| UniProt Synonym Protein Names: | Procollagen COOH-terminal proteinase enhancer 1; PCPE-1; Procollagen C-proteinase enhancer 1; Type 1 procollagen C-proteinase enhancer protein; Type I procollagen COOH-terminal proteinase enhancer |
| Protein Family: | Procollagen C-endopeptidase enhancer |
| UniProt Gene Name: | PCOLCE |
 | Western blot analysis of extracts of U-251MG cells, using PCOLCE antibody (CAB15298) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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