Metabolism Antibodies 3
Anti-PCK2 Antibody (CAB4466)
- SKU:
- CAB4466
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-PCK2 Antibody |
| Antibody SKU: | CAB4466 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human PCK2 |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Mouse lung, Mouse brain, Mouse spleen, Rat kidney |
| Immunogen: | A synthesized peptide derived from human PCK2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 5106 |
| Uniprot: | Q16822 |
| Cellular Location: | |
| Calculated MW: | 71kDa |
| Observed MW: | 71KDa |
| Synonyms: | PEPCK, PEPCK-M, PEPCK2 |
| Background: | This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] |
| UniProt Protein Function: | PCK2: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Monomer. Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.1.1.32; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Kinase, other; Carbohydrate Metabolism - citrate (TCA) cycle; Mitochondrial; Lyase Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:phosphoenolpyruvate carboxykinase (GTP) activity; phosphoenolpyruvate carboxykinase activity; protein binding Biological Process: gluconeogenesis Disease: Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial |
| NCBI Summary: | This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q16822 |
| NCBI GenInfo Identifier: | 290457671 |
| NCBI Gene ID: | 5106 |
| NCBI Accession: | Q16822.3 |
| UniProt Secondary Accession: | Q16822,O43253, Q86U01, Q9BV62, |
| UniProt Related Accession: | Q16822 |
| Molecular Weight: | 47,564 Da |
| NCBI Full Name: | Phosphoenolpyruvate carboxykinase |
| NCBI Synonym Full Names: | phosphoenolpyruvate carboxykinase 2, mitochondrial |
| NCBI Official Symbol: | PCK2 |
| NCBI Official Synonym Symbols: | PEPCK; PEPCK2; PEPCK-M |
| NCBI Protein Information: | phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
| UniProt Protein Name: | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
| Protein Family: | Protein kinase |
| UniProt Gene Name: | PCK2 |
| UniProt Entry Name: | PCKGM_HUMAN |
 | Western blot - PCK2 Rabbit mAb (CAB4466) |
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