Name: Anti-PCDHGC3 Antibody (CAB10235)
Brand: Cell Biology Antibodies 1
SKU: CAB10235
Availability: OutOfStock

Antibody Name:	Anti-PCDHGC3 Antibody
Antibody SKU:	CAB10235
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 32-270 of human PCDHGC3 (NP_002579.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	LO2, MCF7, SW620, Mouse liver, Mouse brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 32-270 of human PCDHGC3 (NP_002579.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	VIHY EIPE EREK GFAV GNVV ANLG LDLG SLSA RRFR VVSG ASRR FFEV NRET GEMF VNDR LDRE ELCG TLPS CTVT LELV VENP LELF SVEV VIQD INDN NPAF PTQE MKLE ISEA VAPG TRFP LESA HDPD VGSN SLQT YELS RNEY FALR VQTR EDST KYAE LVLE RALD RERE PSLQ LVLT ALDG GTPA LSAS LPIH IKVL DAND NAPV FNQS LYRA RVLE DAPS GTRV VQVL ATD
Gene ID:	5098
Uniprot:	Q9UN70
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	94kDa/101kDa
Observed MW:	140kDa

Synonyms:

PCDHGC3, PC43, PCDH-GAMMA-C3, PCDH2

Background:

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

UniProt Protein Function:	PCDHGC3: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 5q31.3 Cellular Component: integral to plasma membrane Biological Process: cell adhesion; cell-cell signaling; nervous system development
NCBI Summary:	This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9UN70
NCBI GenInfo Identifier:	37999813
NCBI Gene ID:	5098
NCBI Accession:	Q9UN70.1
UniProt Secondary Accession:	Q9UN70,O60622, Q08192, Q9Y5C4,
UniProt Related Accession:	Q9UN70
Molecular Weight:	101kDa
NCBI Full Name:	Protocadherin gamma-C3
NCBI Synonym Full Names:	protocadherin gamma subfamily C, 3
NCBI Official Symbol:	PCDHGC3
NCBI Official Synonym Symbols:	PC43; PCDH2; PCDH-GAMMA-C3
NCBI Protein Information:	protocadherin gamma-C3
UniProt Protein Name:	Protocadherin gamma-C3
UniProt Synonym Protein Names:	Protocadherin-2; Protocadherin-43; PC-43
Protein Family:	Protocadherin
UniProt Gene Name:	PCDHGC3

Western blot analysis of extracts of various cell lines, using PCDHGC3 antibody (CAB10235) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.

Antibodies

PCDHGC3 Antibody (PACO11103)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)